Table 2 Possible prediction results of SNPs using software tools in the GABRB1 gene
SNP number | rs74608570 | rs75612351 | rs78815529 |
|---|---|---|---|
Nucleotide change | A > G | C > T | G > T |
Amino acid change | D450G | P458L | W469C |
SIFT results | Damaging | Damaging | Damaging |
SIFT score | 0.013 | 0.001 | 0 |
PolyPhen-2 HumDiv results | Probably damaging | Probably damaging | Probably damaging |
PolyPhen-2 HumDiv score | 0.999 | 0.998 | 1.000 |
PolyPhen-2 HumVar results | Probably damaging | Probably damaging | Probably damaging |
PolyPhen-2 HumVar score | 0.997 | 0.998 | 0.999 |
PROVEAN results | Deleterious | Deleterious | Deleterious |
PROVEAN score | − 5.553 | − 8.026 | − 10.504 |
SNP&GO results | Disease | Disease | Disease |
SNP&GO score | 8 | 8 | 7 |
SNAP2 results | Effect | Effect | Effect |
SNAP2 score | 84 | 62 | 77 |
SNAP2 accuracy rate | 91% | 80% | 85% |
PHD-SNP results | Disease | Disease | Disease |
PHD-SNP RI score | 8 | 8 | 5 |
PANTHER results | Probably damaging | Probably damaging | Probably damaging |
META-SNP results | Disease | Disease | Disease |
META-SNP score | 0.85 | 0.85 | 0.85 |
META-SNP confidence value | 9 | 9 | 8 |
I-Mutant result | Decrease | Decrease | Decrease |
I-Mutant Reliability Index | 2 | 1 | 9 |
I-Mutant DDG value | − 1.44 | − 0.70 | − 1.67 |
MUpro result | Decrease | Increase | Decrease |
MUpro score | − 203.199 | 0.025153447 | − 0.82275225 |