Table 1 Identified genes that have an impact on T2DM among the Iraqi population
From: A meta-analysis and review on genetic mapping of type 2 diabetes mellitus in Iraq
Gene | SNP | Type/position of SNP | No. of patients | No. of controls | Genotype Method | P-Value | OR | City | References | Complications |
|---|---|---|---|---|---|---|---|---|---|---|
GSTM1 | Â | Â | 90 | 30 | PCR-ARMS | 0.055 | 3.06 | Baghdad | Mahmood et al. (2015) | CAD |
ADIPOQ | rs266729 | 5ʹ-UTR | 270 | 135 | PCR–RFLP | 0.001 | 2.45 | Najaf | Ahmed Naseer et al.2015) | No Complications |
TGF-β1 | rs1800469 | – | 50 | 20 | PCR-ARMS | 0.01 | 5.23 | Baghdad | I. A. Hussein (2016) | No Complications |
ADIPOQ | rs1501299 | Intron variant | 100 | 50 | PCR–RFLP | 0.05 | 0.684 | Baghdad | Al-saadi (2016) | No Complications |
ADIPOR2 | rs11061971 | – | 336 | 133 | PCR–RFLP | 0.049 | 1.28 | Najaf | Ismail et al. (2016) | CVD |
FTO | rs9939609 | Intron variant | 800 | 400 | PCR–RFLP | 0.005 | 1.58 | Najaf | Younus et al. (2017) | No Complications |
VCAM-1 | rs3783605 | – | 129 | 61 | PCR-SSP | 0.007 | 1.64 | Baghdad | Salman et al. (2017) | No Complications |
IL-10 | rs1800872 | – | 100 | 30 | PCR–RFLP | 0.05 | 1.5 | Basra | Hamid and Shani (2018) | No Complications |
ADIPOQ | rs2241766 | Missense | 800 | 400 | PCR–RFLP | 0.002 | 1.7 | Najaf | Hussain et al. (2018) | No Complications |
IL-6 | rs1800795 | – | 100 | 50 | PCR–RFLP | 0.03 | 2.17 | Baghdad | Shehab et al. (2018) | No Complications |
PPARG | rs3856806 | – | 100 | 50 | PCR-Taqman | 0.01 | 1.272 | Baghdad | Abd Al-Razzaq et al. (2018) | No Complications |
ELMO1 | rs741301 | – | 73 | 37 | PCR-ARMS | 0.0042 | 4.23 | Kerbala | Mohammed et al. (2019) | DN |
MCP-1 | rs1024611 | – | 235 | 135 | PCR-ARMS | 0.002 | 2.8 | Kerbala | Obied et al. (2019) | DFU |
TCF7L2 | rs7908486 | – | 130 | 60 | PCR–RFLP | 0.035 | 1.301 | Baghdad | Ahmed et al. (2019) | No Complications |
MIR196A2 | rs11614913 | – | 60 | 30 | PCR–RFLP | 0.0001 | 0.22 | Najaf | Jamee et al. (2019) | No Complications |
KCNJ11 | rs5219 | – | 60 | 20 | PCR–RFLP | 0.0014 | 7 | Baghdad | Muftin et al. (2019) | No Complications |
TGF-β1 | rs1800471 | – | 117 | 52 | PCR–RFLP | 0 | 1.89 | Thi-Qar | Nuhiar et al. (2019) | T1DM |
LDLR | A370T | – | 180 | 60 | PCR–RFLP | 0.001 | 1.88457 | Kerbala | Hassan Abo Almaali (2019) | No Complications |
AHSG | rs4918 | – | 200 | 100 | RT-PCR | 0.001 | 0.4 | Kerbala | H. S. M. Ali (2019) | No Complications |
VDR | rs10735810 | – | 77 | 17 | PCR-ARMS | 0.005 | 0.211 | Najaf | Najjar et al. (2020) | DN |
TCF7L2 | rs7903146 | – | 212 | 106 | PCR-ARMS | 0.014 | 1.65 | Erbil | Mustafa et al. (2020) | No Complications |
PD-1 | rs36084323 | – | 90 | 45 | PCR–RFLP | 0.05 | 0.18 | Baghdad | A. R. Rasheed et al. (2020) | No Complications |
ACE | - | – | 242 | 100 | PCR–RFLP | 0.005 | 1 | Baghdad | Dhumad et al. (2020) | No Complications |
LEP | rs7799039 | – | 112 | 50 | PCR–RFLP | 0.0001 | 1.78 | Erbil | G. H. Abdullah (2020) | No Complications |
FTO | rs1588413 | 5ʹ-UTR | 800 | 400 | PCR–RFLP | 0.001 | 4.61 | Najaf | A. Algenabi et al. (2021) | Obesity |
VDR | rs2228570 | Missense | 800 | 400 | PCR–RFLP | 0 | 4.3 | Najaf | Ahmed N Kaftan et al. (2021) | No Complications |
KCNQ1 | rs2237892 | – | 600 | 300 | PCR–RFLP | 0.001 | 2.79 | Najaf | Al Hussieny et al. (2021) | No Complications |
SOST | rs865429 | – | 300 | 150 | PCR–RFLP | 0.0001 | 0.4444 | Najaf | R. A. M. Ali et al. (2021) | CHD |
VDR | rs1544410 | Intron variant | 800 | 400 | PCR–RFLP | 0 | 2.75 | Najaf | Al-Kashwan et al. (2021) | No Complications |
LEP | rs12706832 | – | 220 | 100 | PCR-SSCP | 0.006 | 1.75 | Kerbala | Musafer et al. (2021) | No Complications |
IL-23 | rs1884444 | – | 150 | 75 | PCR-ARMS | 0.001 | 4.2 | Baghdad | S Al-Badri et al. (2022) | No Complications |
ADIPOQ | rs2241766 | Missense | 300 | 150 | PCR–RFLP | 0.002 | 1.918 | Diwaniyah | Abbas et al. (2022) | No Complications |
CDKN2A/B | rs10811661 | Exon variant | 800 | 400 | PCR–RFLP | 0.0001 | 1.918 | Najaf | Fadheel et al. (2022) | No Complications |
APOE | rs429358 | – | 149 | 73 | Conventional-PCR | 0.037 | 1 | Baghdad | Hameed et al. (2023) | CVD |
IL-17A | rs2275913 | – | 150 | 75 | PCR-ARMS | 0.001 | 0.29 | Kut | Ali Saad Kadhim (2023) | Oral fungi |
GSTP1 | rs1138272 | Exon variant | 90 | 30 | PCR-ARMS | 0.019 | 1.65 | Babylon | Neama et al., (2023) | No Complications |
CNDP1 | rs2887 | Â | 100 | 50 | PCR-HRM | 0.001 | 2.77 | Baghdad | Shaheed and Ali (2023) | No Complications |
PON1 | rs705379 |  | 100 | 40 | PCR–RFLP | 0.0001 | 5.7 | Babylon | AbdAli et al. (2023) | No Complications |
WFS1 | rs734312 | – | 200 | 100 | RT-PCR | 0.0001 | 0.86 | Diwaniyah | A. J. Hussein et al. (2023) | No Complications |
TNF-α | rs1800629 | – | 100 | 50 | RT-PCR | 0.0001 | 1.52 | Diyala | Alaa N. Lateef (2023) | No Complications |
PPARG | rs1801282 | – | 200 | 100 | Sanger-PCR | 0.0045 | 3.96 | Erbil | Baqer et al. (2023) | No Complications |