Association of IL-1β rs16944 and IL-1RN rs2234663 gene polymorphisms with graft function in renal transplant recipients

Egyptian Journal of Medical Human Genetics

Table 3 Frequency distribution of IL-1RN (VNTR) and IL-1β − 511C/T gene polymorphisms and IL-1RN/IL-1β haplotypes in renal transplant recipients and healthy controls

Gene polymorphism	Renal transplant recipients (n = 31)	Healthy controls (n = 26)	p-value
IL-1RN genotypes
11	22 (71%)	14 (53.8%)	0.270
12 + others^†	9 (29%)	12 (46.2%)
IL-1β genotypes
CC	7 (22.6%)	6 (23.1%)	1.000
CT + TT	24 (77.4%)	20 (76.9%)
IL-1RN/IL-1β haplotypes
*1/C	24/62 (38.71%)	24/52 (46.15%)	0.259
Others^‡	38/62 (61.29%)	28/52 (53.85%)

IL-1RN Interleukin-1 receptor antagonist, IL-1β, Interleukin-1β
^†IL-1RN genotypes ‘others’ include the less frequent genotypes IL-1RN *2*2, *3*3, *2*4 and *1*3
^‡IL-1RN/IL-1β haplotypes ‘others’ include the less frequent haplotypes *1/T, *2/C, *2/T, *3/C, *3/T and*4/T
p value ≤ 0.05 is considered to be statistically significant