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Egyptian Journal of Medical Human Genetics

Table 4 Association of IL-1RN (VNTR) and IL-1β − 511 C/T gene polymorphisms and IL-1RN/IL-1β haplotypes with graft function in Renal Transplant Recipients

From: Association of IL-1β rs16944 and IL-1RN rs2234663 gene polymorphisms with graft function in renal transplant recipients

Gene polymorphism

Renal transplant recipients (n = 31)

p-value

Stable allograft function (Group I) (n = 8)

Early renal allograft dysfunction (Group II) (n = 23)

IL-1RN genotypes

 *1*1

7 (87.5%)

15 (65.2%)

0.379

 *1*2 + others†

1 (12.5%)

8 (34.8%)

 

IL-1β genotypes

 CC

6 (75%)

1 (4.3%)

 < 0.001

 CT + TT

2 (25%)

22 (95.7%)

 

IL-1RN/IL-1β haplotypes

 *1/C

11/16 (68.75%)

13/46 (28.26%)

 < 0.001

 Others‡

5/16 (31.25%)

33/46 (71.74%)

 
  1. IL-1RN Interleukin-1 receptor antagonist, IL-1β Interleukin-1β
  2. †IL-1RN genotypes ‘others’ include the less frequent genotypes IL-1RN *2*2, *3*3, *2*4 and *1*3
  3. ‡IL-1RN/IL-1β haplotypes ‘others’ include the less frequent haplotypes *1/T, *2/C, *2/T, *3/C, *3/T and*4/T
  4. p value ≤ 0.05 is considered to be statistically significant
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