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Egyptian Journal of Medical Human Genetics
Fig. 1 | Egyptian Journal of Medical Human Genetics

Fig. 1

From: Effect of oxidative stress-related genetic variants: “Explicating the role of reactive oxygen species influenced antioxidant gene polymorphism,” a risk stratification of type 2 diabetes mellitus-associated nephropathy: a systematic review

Fig. 1

Schematic representation of antioxidant gene polymorphism in the oxidative stress-induced diabetic nephropathy. 1. Mechanism of oxidative stress a. kidney injury and b. antioxidants (SOD, CAT, GST, and GPx) depletion. 2. Lifestyle modification-induced oxidative stress stimulates gene polymorphism. 3. Oxidative stress stimulates insulin resistance. 4. Insulin resistance causes T2D complication like CKD. 5. Kidney injury biomarkers stimulate antioxidant gene polymorphism. 6. Inherited genetic variant can express and leads to hyperglycemia. 7. ROS-mediated hyperglycemia in turn causes antioxidant gene polymorphism

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