Egyptian Journal of Medical Human Genetics

Table 1 Overview of antioxidant gene characteristics

From: Effect of oxidative stress-related genetic variants: “Explicating the role of reactive oxygen species influenced antioxidant gene polymorphism,” a risk stratification of type 2 diabetes mellitus-associated nephropathy: a systematic review

S.No	Gene	Cytogenetic region	SNP ID	Allelic variants	References
1	SOD isoforms
	SOD1	21q22.11
	SOD2	6q25.3	rs4880	A > G	[23, 25, 31, 42]
	SOD3	4p15.2
2	CAT isoforms
	CAT1	11p13.34	rs1049982	T > A	[28, 42]
	CAT2
	CAT3
3	GPx isoforms
	GPx1	3q21.31	rs1050450	G > C	[41, 43]
	GPx2	14q23.3
	GPx3	5q33.1
	GPx4	19p13.3
	GPx5	6p22.1
	GPx6	6p22.12
	GPx7	1p32.3
	GPx8	5q11.2
4	GST isoforms
	GSTM1	1p13.3	rs35553604	C > G	[32, 33, 35, 37,38,39]
	GSTT1	22q11.23
	GSTP1	11q13.12	rs1695	A > G
5	Nrf2	2q31.2	rs6721961	T > A,C,G	[49,50,51,52,53]
	Nrf2-Keap1	19p13.2

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