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Table 3 The relation between the c-MYC amplification and other ACAs by FISH analysis

From: The study of the impact of additional chromosomal aberrations and c-MYC and BCR::ABL1 genes amplification on CML patient’s characteristics: relation to haematological parameters and patient outcome

 

c-MYC amplification

Test value*

P value

Negative

c-MYC amplification

No. = 43

No. = 6

FISH

Ph only

30 (69.8%)

1 (16.7%)

6.388

0.011

Ph with other abnormalities

13 (30.2%)

5 (83.3%)

Double ph

Negative

40 (93.0%)

6 (100.0%)

0.446

0.504

Positive

3 (7.0%)

0 (0.0%)

8 + 

Negative

40 (93.0%)

1 (16.7%)

22.472

0.000

Positive

3 (7.0%)

5 (83.3%)

9 + 

Negative

42 (97.7%)

5 (83.3%)

2.766

0.096

Positive

1 (2.3%)

1 (16.7%)

Del 9q

Negative

37 (86.0%)

6 (100.0%)

0.954

0.329

Positive

6 (14.0%)

0 (0.0%)

  1. P value > 0.05: Nonsignificant; P value < 0.05: Significant; P value < 0.01: Highly significant
  2. *: Chi-square test. FISH; Fluorescence in situ hybridization; Double Ph: double Philadelphia; Sig: significancy; NS: nonsignificant; S: significant