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Table 4 The relation between the BCR::ABL1 and ABL amplification and other clinical features and haematological parameters

From: The study of the impact of additional chromosomal aberrations and c-MYC and BCR::ABL1 genes amplification on CML patient’s characteristics: relation to haematological parameters and patient outcome

 

BCR::ABL1 and ABL amplification

Test value

P value

Negative

ABL

BCR::ABL 1

No. = 42

No. = 4

No. = 3

Age

Mean ± SD

47.2 ± 15.2

39.5 ± 16.0

51.6 ± 5.5

0.645•

0.529

Range

20–75

20–58

46–57

Sex

Female

24 (57.1%)

1 (25.0%)

1 (33.3%)

2.014*

0.365

Male

18 (42.9%)

3 (75.0%)

2 (66.7%)

Spleen

Moderate

16 (38.1%)

1 (25.0%)

1 (33.3%)

0.285*

0.867

Huge

26 (61.9%)

3 (75.0%)

2 (66.7%)

TLC

Median (IQR)

101.5 (54–199)

64 (35–149)

57 (41–109)

2.252 ≠ 

0.324

Range

32–283

29–211

41–109

Hb

Mean ± SD

8.7 ± 1.3

9.0 ± 1.3

7.2 ± 0.5

1.885•

0.163

Range

6.3–11.1

8–11

6.9–7.9

Plat

Median (IQR)

410.5 (93–545)

310 (84–547)

54 (34–82)

5.502 ≠ 

0.064

Range

45–900

78–564

34–82

PB blast

Median (IQR)

4 (3–9)

7.5 (3.5–15.5)

23 (12–25)

6.983 ≠ 

0.030

Range

1–36

3–20

12–25

BM blasts

Median (IQR)

8 (6–15)

10 (6.5–22)

35 (18–61)

4.861 ≠ 

0.088

Range

5–53

6–31

18–61

  1. P value > 0.05: Nonsignificant; P value < 0.05: Significant; P value < 0.01: Highly significant
  2. *: Chi-square test; •: One-Way ANOVA test; ≠ : Kruskal–Wallis test. TLC: total leucocytic count; Hb: haemoglobin; Plat: platelet; PB blast: peripheral blood blast; BM blasts: bone marrow blasts