Table 1 Laboratory data of patients before and after treatment of hydroxycobalamin, folate, betaine, and calcium folinate

Age

2m1d

1y7m

1y9m

1y11m

Routine blood test

Hb (g/L) (90–140)

71

124

121

115

RBC (10¹²/L) (3.2–4.9)

2.22

4.38

4.43

4.20

MCV (fL) (75–121)

95.0

84.0

88.3

88.3

WBC (10⁹/L) (5–12)

3.26

10.83

9.83

7.34

ANC (10⁹/L) (1.08–5.9)

0.46

6.19

4.03

2.33

Plt (10⁹/L) (100–378)

61

366

238

315

Vitamin B12 (pg/mL) (139.4–651.5)

Normal

Folate (nmol/l) (7.0–46.4)

Normal

Methionine (μmol/L) (10–50)

4.67

7.96

9.50

11.20

Plasma tHcy (μmol/L) (5–15)

92.25

79.14

48.54

14.68

Methylmalonic acid (μmol/L)(0.2–3.6)

0.20

0.32

0.26

0.30