Association between genetic polymorphisms and other attributing factors with lipid profiles among statin users: a cross-sectional retrospective study

Shamsudin, Amirul Faez; Sulong, Sarina; Ahmad, Imran; Bakar, Nur Salwani

doi:10.1186/s43042-024-00523-4

Egyptian Journal of Medical Human Genetics

Table 4 Lipid profiles between homozygous dominant and heterozygous + homozygous recessive groups for each SNP at the baseline and after statin treatment

From: Association between genetic polymorphisms and other attributing factors with lipid profiles among statin users: a cross-sectional retrospective study

SNP	Genotype (n)	Lipid levels (mmol/L), mean ± SD
		TC				HDL-c				LDL-c				TG
		Baseline	0–6 months	7–12 months	P-value A	Baseline	0–6 months	7–12 months	P-value A	Baseline	0–6 months	7–12 months	P-value A	Baseline	0–6 months	7–12 months	P-value B
ABCG2 rs2231142	GG (n = 192)	5.66 ± 1.18	4.81 ± 1.00	4.85 ± 1.04	P < 0.001^c P1 < 0.001 P2 < 0.001 P3 = 0.550	1.25 ± 0.26	1.21 ± 0.26	1.26 ± 0.27	P = 0.646^c	3.69 ± 1.15	2.94 ± 0.93	2.90 ± 0.85	P < 0.001^c P1 < 0.001 P2 < 0.001 P3 = 0.831	1.64 ± 0.77	1.67 ± 0.97	1.56 ± 0.85	P = 0.050^d
	GT + TT (n = 37)	5.92 ± 1.11	4.79 ± 0.93	5.13 ± 1.23	P < 0.001^d P1 < 0.001 P2 = 0.025 P3 = 0.067	1.38 ± 0.37	1.24 ± 0.14	1.28 ± 0.35	P = 0.030^d P1 = 1.000 P2 = 0.066 P3 = 0.234	3.75 ± 1.08	2.85 ± 0.79	3.15 ± 1.02	P < 0.001^d P1 < 0.001 P2 = 0.042 P3 = 0.040	1.56 ± 0.86	1.51 ± 0.66	1.52 ± 0.91	P = 0.148^d
	P-value B	0.238^a	0.746^b	0.038^b	–	0.035^b	0.300^b	0.990^b	–	0.757^a	0.693^a	0.080^b	–	0.353^b	0.715^b	0.392^b	–
ABCC2 rs717620	CC (n = 15)	5.17 ± 0.97	4.76 ± 0.92	4.78 ± 0.97	P = 0.307^d	1.24 ± 0.22	1.25 ± 0.18	1.22 ± 0.27	P = 0.605^d	3.08 ± 1.03	2.78 ± 0.89	2.70 ± 0.87	P = 0.225^d	1.86 ± 0.88	1.62 ± 0.62	2.17 ± 1.14	P = 0.938^d
	CT + TT (n = 111)	5.79 ± 1.11	4.81 ± 1.07	4.92 ± 1.07	P < 0.001^d P1 < 0.001 P2 < 0.001 P3 = 0.535	1.26 ± 0.30	1.21 ± 0.27	1.28 ± 0.30	P = 0.851^d	3.79 ± 1.09	2.92 ± 0.90	2.97 ± 0.95	P < 0.001^d P1 < 0.001 P2 < 0.001 P3 = 1.000	1.57 ± 0.84	1.57 ± 0.92	1.48 ± 0.75	P = 0.061^c
	P-value B	0.040^a	0.910^a	0.623^a	–	0.994^b	0.576^a	0.355^a	–	0.022^b	0.688^a	0.319^a	–	0.120^b	0.429^b	0.009^b	–
GATM rs9806699	GG (n = 39)	5.75 ± 1.31	4.99 ± 0.89	5.07 ± 1.06	P < 0.001^c P1 < 0.001 P2 < 0.001 P3 = 0.497	1.29 ± 0.23	1.26 ± 0.28	1.26 ± 0.23	P = 0.161^d	3.73 ± 1.23	2.96 ± 0.85	3.05 ± 0.95	P < 0.001^d P1 < 0.001 P2 < 0.001 P3 = 0.749	1.62 ± 0.69	1.70 ± 0.97	1.72 ± 1.15	P = 0.678^c
	GA + AA (n = 190)	5.69 ± 1.14	4.77 ± 1.01	4.86 ± 1.08	P < 0.001^d P1 < 0.001 P2 < 0.001 P3 = 0.953	1.27 ± 0.29	1.20 ± 0.23	1.27 ± 0.29	P = 0.862^d	3.69 ± 1.12	2.92 ± 0.93	2.91 ± 0.91	P < 0.001^d P1 < 0.001 P2 < 0.001 P3 = 1.000	1.63 ± 0.80	1.63 ± 0.93	1.52 ± 0.79	P = 0.010^c P1 = 0.009 P2 = 0.008 P3 = 0.972
	P-value B	0.810^a	0.338^a	0.272^b	–	0.301^b	0.307^a	0.848^b	–	0.845^a	0.826^a	0.521^b	–	0.725^b	0.475^b	0.248^b	–
COQ2 rs4693075	GG (n = 5)	6.61 ± 1.26	4.68 ± 0.36	4.92 ± 1.50	P = 0.097^c	1.34 ± 0.14	1.29 ± 0.42	1.31 ± 0.29	P = 1.000^c	4.60 ± 1.26	2.46 ± 0.87	3.00 ± 1.62	P = 0.097^c	1.70 ± 1.11	2.05 ± 2.30	1.30 ± 0.73	P = 0.717^c
	GC + CC (n = 224)	5.68 ± 1.16	4.81 ± 1.00	4.90 ± 1.07	P < 0.001^d P1 < 0.001 P2 < 0.001 P3 = 0.565	1.27 ± 0.29	1.21 ± 0.24	1.27 ± 0.28	P = 0.438^c	3.68 ± 1.13	2.94 ± 0.91	2.93 ± 0.90	P < 0.001^d P1 < 0.001 P2 < 0.001 P3 = 1.000	1.62 ± 0.78	1.64 ± 0.90	1.56 ± 0.86	P = 0.017^c P1 = 0.010 P2 = 0.020 P3 = 0.816
	P-value B	0.079^a	0.969^b	0.613^b	–	0.416^b	0.551^a	0.596^b	–	0.072^a	0.368^a	0.488^b	–	0.866^b	0.410^b	0.319^b	–
APOA5 rs662799	AA (n = 59)	5.50 ± 1.21	4.77 ± 1.16	4.80 ± 0.75	P < 0.001^d P1 = 0.003 P2 = 0.002 P3 = 1.000	1.18 ± 0.23	1.15 ± 0.26	1.19 ± 0.20	P = 0.806^c	3.58 ± 1.17	2.86 ± 0.97	2.87 ± 0.64	P = < 0.001^d P1 = 0.005 P2 = 0.002 P3 = 1.000	1.64 ± 0.74	1.67 ± 0.89	1.64 ± 0.58	P = 0.925^c
	AG + GG (n = 170)	6.00 ± 1.10	4.67 ± 0.81	4.92 ± 1.02	P < 0.001^c P1 < 0.001 P2 < 0.001 P3 = 0.383	1.27 ± 0.25	1.25 ± 0.24	1.27 ± 0.25	P = 0.757^d	3.96 ± 1.02	2.77 ± 0.73	2.93 ± 0.90	P < 0.001^c P1 < 0.001 P2 < 0.001 P3 = 0.668	1.70 ± 0.81	1.56 ± 0.83	1.57 ± 0.97	P = 0.003^c P1 = 0.003 P2 = 0.004 P3 = 0.909
	P-value B	0.638^a	0.397^a	0.598^b	–	0.007^b	0.168^a	0.031^b	–	0.888^a	0.839^a	0.319^b	–	0.406^b	0.092^b	0.037^b	–
APOE (rs429358 & rs7412)	E3E3 (n = 101)	5.73 ± 1.25	4.79 ± 0.99	4.84 ± 1.17	P < 0.001^d P1 < 0.001 P2 < 0.001 P3 = 1.000	1.30 ± 0.32	1.23 ± 0.24	1.28 ± 0.31	P = 0.791^d	3.73 ± 1.24	2.96 ± 0.98	2.90 ± 0.98	P < 0.001^d P1 < 0.001 P2 < 0.001 P3 = 1.000	1.56 ± 0.72	1.48 ± 0.56	1.45 ± 0.72	P = 0.851^c
	E3E4 + E4E4 (n = 128)	5.68 ± 1.11	4.83 ± 1.00	4.94 ± 1.00	P < 0.001^d P1 < 0.001 P2 < 0.001 P3 = 0.606	1.25 ± 0.25	1.19 ± 0.24	1.26 ± 0.26	P = 0.766^d	3.67 ± 1.05	2.90 ± 0.86	1.96 ± 0.87	P < 0.001^c P1 < 0.001 P2 < 0.001 P3 = 1.000	1.66 ± 0.84	1.77 ± 1.13	1.62 ± 0.94	P = 0.003^c P1 = 0.002 P2 = 0.005 P3 = 0.829
	P-value B	0.732^a	0.948^b	0.457^b	–	0.452^b	0.440^b	0.755^b	–	0.715^a	0.695^b	0.696^b	–	0.745^b	0.663^b	0.167^b	–

^aP-value was obtained using independent t-test
^bP-value was obtained using Mann–Whitney U test
^cP-value was obtained using Friedman test
^dP-value was obtained using one way repeated measurement ANOVA and Bonferroni adjustment were performed for post hoc analysis; P-value A, comparisons of lipid levels within the particular genotype; P-value B, comparisons of the particular lipid level between wild-type and heterozygous + homozygous recessive genotypes; P1, comparison of baseline lipid levels vs 0–6 months after statin treatment; P2, comparison of baseline lipid levels vs. 7–12 months after statin treatment; P3, comparison of lipid levels between 0–6 months treatment and 7–12 months after statin treatment. P < 0.05 is considered as statistically significant (indicated by bold text)

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