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Table 4 Statistical comparison of PTPN11 hotspot exon mutation rates through worldwide populations

From: Molecular and environmental characterization of Noonan syndrome in Morocco reveals a significant association with consanguinity and advanced parental age

ContinentNoonan populationMutational rate of exons 2, 3, 4, 7, 8, 12, and 13p value*Reference
AfricaEgyptian1/21 (4.7)0.4[10]
Tunisian6/19 (31.6)0.3[11]
Total7/40 (17.5)0.8
EuropeTurkish6/26 (23)0.5[12]
Turkish11/30 (36.7)0.06[13]
Dutch56/170 (32.9)0.06[14]
Italian21/71 (29.6)0.1[15]
Italian14/40 (31.5)0.07[16]
Greek17/60 (28.3)0.2[17]
German16/29 (55)0.001**[18]
German34/57 (59.6)0.0001**[19]
German23/79 (29)0.1[20]
Total198/562 (35.2)0.03**
AmericaBrazilian7/14 (50)0.03**[21]
Brazilian20/50 (42)0.02**[22]
American54/119 (45)0.003**[5]
American33/65 (50.7)0.001**[23]
American11/22 (50)0.008**[24]
Total125/270 (46.3)0.001**
AsiaTaiwanese13/34 (38.2)0.04**[25]
Japanese7/21 (33.3)0.1[26]
Japanese16/41 (39)0.03**[27]
Japanese18/45 (40)0.02**[28]
Korean10/18 (55.6)0.003**[29]
Korean23/59 (38.9)0.02**[30]
Korean7/14 (50)0.03**[31]
Korean16/59 (27.1)0.2[32]
Total110/291 (37.8)0.01**
Total (all studies) 440/1163 (37.8)0.01**
Present studyMoroccan5/31 (16.1)
  1. *Compared to the present study
  2. **Significant difference