Skip to main content
Egyptian Journal of Medical Human Genetics
Download PDF

Association of genetic variants with prostate cancer in Africa: a concise review

Egyptian Journal of Medical Human Genetics volume 22, Article number: 33 (2021) Cite this article

Abstract

Background

Prostate cancer (PCa) has one of the highest heritability of all major cancers, where the genetic contribution has been documented, and knowledge about the molecular genetics of the disease is increasing. However, the extent and aspects to which genetic variants explain PCa heritability in Africa are limited.

Main body

In this review, we summarize studies that highlight how identified genetic variants explain differences in PCa incidence and presentation across ethnic groups. We also present the knowledge gaps in PCa genetics in Africa and why Africa represents an untapped potential ground for genetic studies on PCa. A significant number of genome-wide association studies, linkage, and fine-mapping analyses have been conducted globally, and that explains 30–33% of PCa heritability. The African ancestry has a significant mention in PCa incidence and presentation. To date, the candidate gene approach has replicated 23 polymorphisms including dinucleotide and trinucleotide repeats in 16 genes. CYP17-rs743572, CYP3A4-rs2740574, CYP3A5-rs776746, CYP3A43-rs501275, and haplotype blocks, containing these variants, are significantly associated with PCa among some population groups but not others. With the few existing studies, the extent of genetic diversity in Africa suggests that genetic associations of PCa to African ancestry go beyond nucleotide sequence polymorphisms, to a level of environmental adaptation, which may interpret genetic risk profiles. Also, the shreds of evidence suggest that evolutionary history contributes to the high rates of PCa relative to African ancestry, and genetic associations do not always replicate across populations.

Conclusion

The genetic architecture of PCa in Africa provides important contributions to the global understanding of PCa specifically the African-ancestry hypothesis. There is a need for more prostate cancer consortiums to justify the heritable certainties of PCa among Africans, and emphasis should be placed on the genetic epidemiological model of PCa in Africa.

Background

Prostate cancer (PCa) is the fifth leading cause of death from cancer in men, with an estimated 307,000 deaths representing 6.6% of total male cancer mortality [1]. Among men of African descent, PCa is the leading cancer in terms of incidence and mortality with approximately 22.0 per 100,000 population of men affected [2]. There is a consensus that 56% of new cases of cancers are reported in Africa and other low-middle-income countries which are projected to reach about 70% by 2030 [3,4,5]. Regional reports indicate that the age-adjusted incidence per 100,000 population ranges from 10.6 in Northern Africa to 61.7% in Southern Africa [6]. In sub-Saharan Africa (SSA) alone, disability-adjusted life years (DALYs) and mortality from prostate cancer increased from 100,200 to 219,700 and 5600 to 12,300, respectively over a decade (1990–2010) [7, 8]. Until recently, major unexplained differences exist in PCa incidence and mortality between countries in Africa, subjected to socioeconomic factors and genetics. For example, the age-standardized PCa incidence rate per 100,000 is 37.1 in Uganda [9], 30.5 in Benin [10], 30.26 in Eritrea [11], 24.5 in Mozambique [12], 20.4 in Northern Uganda [13], 16.5 in Mauritius [14], and 4.3 in Eastern Morocco [15]. Aside from these African continent-specific differences, there are also significant geographical differences largely due to the underlying biology of prostate carcinogenesis, the variation in access to screening and treatment, and exposure to risk factors of PCa [6]. However, the proportion of racial, ethnic, or geographical differences in PCa incidence that can be explained by these factors is relative and poorly understood.

PCa has one of the highest heritability of all major cancers [16,17,18,19], where the genetic contribution to PCa risk has been documented and knowledge about the molecular genetics of the disease is increasing and evolving. For instance, family based linkage studies have identified both common and ethnic-specific loci that partly explain the diversity in PCa incidence. Linkage signals including 12q24, 1q24-25, and 8q24 are common to both European and non-European descendants and have been widely replicated in candidate gene studies across diverse ethnic groups [20]. Also, as of 2014, genome-wide association studies (GWAS) have identified 76 susceptibility loci associated with PCa risk, and approximately 30% of the familial risk is due to such variants [21]. This typifies that understanding the genetic risks of PCa is essential to personalized medicine and a bridge in understanding differences in incidence and mortality outcomes.

In this study, we review topics covered on the genetics of PCa in Africa from January 1990 to September 2020 with detailed sections on (1) inheritance and African-associated risk, (2) GWAS, and (3) candidate gene studies in PCa. The review also highlighted the gaps in knowledge and prospects in the field to translate the clinical utility of these genetic variants, hitherto undecided. Our literature search included Google Scholar, PubMed, Web of Science, and Scopus. Medical Subject Heading (MeSH) Terms of PCa (Prostatic Neoplasms) were tagged to all countries in Africa across the online databases.

Inheritance and African-associated PCa risk

In 2015, a study among first-degree relatives in Senegal revealed that being black and having a first-degree relative with PCa does not appear to increase the risk of PCa [22]. While this finding remains to be confirmed or refuted among other African populations, several studies [23,24,25,26] among men with African heritage have reported a strong familial aggregation of PCa. Unfortunately, comprehensive meta-analyses conducted thus far, which provide evidence of familial aggregation of PCa, did not include any study from Africa. Thus, there are unclear answers to what aspects of genetic risk contribute to PCa incidence in Africa. Accordingly, familial studies are needed to evaluate the true estimate of PCa heritability in Africa.

Petersen et al. [27] reported a stronger link between KhoeSan ancestry (in South Africa) and high-risk of PCa, which can explain a 2-fold increase in PCa presentation in Black South Africans compared with African Americans (AA). Typical of this finding, the genetic contribution to the burden of PCa among AA has been traced to West/West-Central Africa that shares about 82% of their ancestral genes [27, 28]. To hold this fact, it means that modern men of African ancestry are not unlikely to have undergone selective pressure and possess PCa risk signatures in their genome with possible familial aggregation. Accordingly, these signatures may be conserved in men of African ancestry including the AA, which may clarify the unexplained 57% PCa heritability among such populations [19]. Comprehensive studies on familial aggregation of PCa among Africans, especially men from West/Western-central Africa, are needed to understand population risk and extract evidence for personalized preventive strategies.

Risk alleles at 8q24 region in the African population

Various models have been employed to uncover the landscape of genetic variations associated with PCa. In Africa, the GWAS and candidate gene association approach are the most used models. Genetic variants of moderate-to-low-risk rather than rare variants with high penetrance have been widely investigated across Africa, especially the African MadCap Network. The first study that tested the transferability of European and AA common shared variants [20] in the West-African population (Nigeria and Cameroon) observed that SNPs rs6983561, rs7008482, and rs16901979 were significantly associated with PCa risk [29]. At the same time, they reported that SNPs rs6983267, rs7008482, and rs7000448 which have low penetrance (2–4%) in the European population were prevalent in more than 84% of the West African population. Similarly, a prior study by Haiman et al. [30] reported that the risk allele at the strongest SNP-rs16901979 associated with PCa revealed higher penetrance in West Africans (54%) than European Americans (3%).

Han et al. [31] conducted a fine mapping of the 8q24 PCa-risk region (127.8–128.8Mb) to search for novel associations with common and rare variations among men of African Ancestry. Three ancestry-specific signals (rs72725879, rs114798100, and rs111906932), one of which is novel (rs111906932) located within or near some PCa-associated long noncoding RNAs (lncRNAs), including PRNCR1, PCAT1, and PCAT2, were identified. These associations were replicated in Ghanaian and Ugandan men [31]. Also, a comprehensive resequencing analysis of 250kb region of 8q24.21 in Ghanaian men replicated similar findings [32]. Similarly, 8q24 risk region marked by ancestry-specific risk variant rs72725854, near lncRNAs of PCAT1, accounted for 12% of PCa risk in the Ugandan population [33]. Moreover, regions marked by rs7008482 and rs6983267 were replicated in the Black South African mixed population [34]. The report of Chung et al. [32] indicated that all 8 PCa-associated loci and rs13252298 in 8q24 are monomorphic in the Ghanaian population. This represents that both ancestry-specific rare and common variants, as well as commonly shared variants, are present in the African population. For all the studies, West African men have a much higher prevalence of 8q24-risk alleles than other populations of European and Asian ancestry which may explain the African-ancestry risk burden of PCa among AA population.

The overall findings suggest that rarer genetic variation in the 8q24 region may contribute, in part, to the greater risk of PCa among the African population. Ahmadiyeh et al. [35] demonstrated that several independent polymorphic variants on chromosome 8q24 may produce a conventional biological mechanism that promotes the disease or regulation of nearby genes (cis-regulation) or genes on other chromosomes (trans-regulation). Pomerantz et al. [36] also indicated that the 8q24 locus harbors previously unannotated microRNAs (miRNAs) which are involved in cis-regulation of distal genes and affecting RNA expression.

The significance of 8q24-risk alleles has been demonstrated in a recent study among the Ugandan population [33]. Polygenic risk score including 8q24-risk alleles has 2-times predictive ability than score constructed without 8q24-risk alleles [33], suggesting that variation in this region may prove vital for risk classification among the African population. Common variants including rs7008482, rs72725879, and rs114798100 were transferable in more than one population group in Africa (Table 1). However, rs6983561 and rs16901979 were replicated in some population group in Africa but not others (Table 1), although there were relatively high allele frequencies in such populations. This finding also suggest that population structure and context-specific factors influence the definition of risk alleles for a population group.

Table 1 Common and rare variants associated with PCa among African population (January 1990–September 2020)
Full size table

Other risk variants from genome-wide association studies

In GWAS [37, 38], 30 variants were identified to be associated with PCa in a prostate cancer study in a Ghanaian population. However, the most promising association was the 10p14 locus marked by introns of noncoding RNAs (rs7918885; 358kb 5′ of GATA3, RP11-543F8), which depicts evidence of transferability in the AA population. Subgroup analysis revealed variants at 5q31 (lead SNP PCDHA1-rs34575154), 22q13.31 (CELSR1-rs6008813), 7q31.31 (rs12537079; 61kb 5′ of AC003084.2; 119kb 5′ of NAA38), and 2q14.2 (rs12477565; AC012363.13; 22kb 5′ of INHBB), associated with GS≥7 cancers. SNPs at Xq28 (rs985081; 22kb 3′ of IDS) and 6q21 (rs2185710; 84kb 3′ of U6) were associated with low GS <7 cancers.

In a genome-wide association meta-analysis among men of African ancestry, 13q34 candidate signals located 5′ of the gene IRS2 and 3′ of a long noncoding RNA (rs75823044) and 22q12.1 candidate functional allele in the CHEK2 gene were novel signals found only in men of African ancestry [39]. Additionally, according to Fernandez et al. [34], rs10993994 (10q11) showed evidence of transferability in South-African mixed ancestry men. A study by Petersen et al. [27] among the South African Black population identified loci at 2p11.2, 3p14, 8q23, and 22q13.2 associated with the aggressive presentation of PCa. In a further comparative analysis using Fisher’s exact significance test with Bonferroni correction, 22q13.2 and 2p11.2 were associated with Gleason score (GS) >8. Also, 2p11.2 was associated with PSA ≥ 20 ng/ml, whereas 8q23 and 3p14 were found to be associated with PSA-High-risk prostate cancer. Haplotype and single-marker association analysis identified rs10103786 and rs4504665 within 8q23 that remained significant after correcting for multiple testing [27]. The loci enriched with GS ≥ 8 and PSA ≥ 20 ng/ml, 22q13.2 and 2p11.2, have shown evidence of transferability among different population groups [40,41,42,43]. The pattern of PCa risk allele identification from GWAS is typical of a recent report by the MadCap Network that there are significant individual and population-level differences in PCa risk within the Africa population [44]. Among men of African ancestry, Haiman et al. [45] identified novel risk variants on 17q21 (rs7210100; odds ratio per allele=1.51; p=3.4×10−13), which has approximately 5% penetrance among AA compared with 1% in the white race. These findings emphasized the significance of GWAS for discovering significant PCa rare variants associated with the African race [45].

Candidate gene studies

From January 1990 to September 2020, only 23 polymorphisms, including dinucleotide and trinucleotide repeats, in 16 genes, have been investigated in association with PCa in Africa. The cytochrome variants involved in androgen and estrogen metabolism [46,47,48,49,50,51,52] and variants involved in cell proliferation and inflammation (COX-2 and GSTS genes) [53,54,55,56] have been investigated in multiple studies. CYP17-rs743572, CYP3A4-rs2740574, CYP3A5-rs776746, CYP3A43-rs501275, and haplotype blocks containing these variants were significantly associated with PCa among Tunisians and the South African population [46, 47, 49]. However, the association of CYP3A4-rs2740574 and CYP3A5-rs776746 with PCa was not replicated among Senegalese men [49]. COX-2 polymorphisms (rs3918304 and rs20415) [53] and rs2745557 [54] were transferable to South African and Egyptian populations, respectively. Whereas polymorphisms in GSTM1 but not GSTT1 were associated with PCa in the Tunisian population [55], the association was reciprocated in the Algerian population [56]. Other markers involved in nucleotide excision repair (XPC gene) [57], regulation of cell-cycle progression (ELAC2 gene) [58], and regulation of androgen receptor (HSP70 and AR genes) [59, 60], and COMT [52], studied in single studies, were found to be significantly associated with PCa risk and severity.

Genetic epidemiological layout of PCa in Africa

Taking together the shreds of evidence from GWAS and candidate gene association studies, the genetic epidemiological layout of PCa among the African population is shown in Fig. 1. It appears that the genetic risk of PCa is more complex and results from polygenic inheritance. The focus of research, thus far, has been on African-ancestry risk rather than familial aggregation to identify rare variants with larger effect sizes. The 8q24 locus has the highest number of independently associated common and ancestry-specific variants, which might be clinically relevant. Du et al. [41] have demonstrated that chromatin conformation of 8q24 SNPs exerts long-range tissue-specific control on MYC expression which gives potential insight into the pathogenesis of prostate cancer. Du et al. [33] further attempted to use risk variants at 8q24 for risk profiling and exhibited that variation in this region may prove vital for risk classification among the African population. It thus, highlights that population genetic risk score distribution at this region could potentially differentiate PCa risks for men more accurately according to their risk score percentile. For example, Ugandan men within the 90–99% of genetic risk scores constructed with 8q24-risk alleles were 4 times more at risk of PCa.

Fig. 1
figure 1

Supposed genetic epidemiological of PCa among the African population. The blue boxes indicate that replication studies in a wider population group of Africans are needed to confirm their clinical and epidemiological usefulness. The green boxes also indicate the variants are beneficial for population-level profiling to uncover both global cosmopolitan and ancestry-specific signals. Moreover, the orange boxes indicate that comprehensive studies are warranted to understand the contribution of genetic to PCa inheritance

Full size image

Additionally, other chromosomal aberrations at 2p11, 3p14, 8q23, 13q34, 5q31, 7q31, and 22q13 are associated with the aggressive presentation of PCa among the West African population. Evidence from genetic association studies also affirms the genetic contribution to PCa among Africans. Generally, variations in androgen and estrogen metabolism genes, cell proliferation genes, and genes involved in inflammation have a high effect on PCa susceptibility (Table 2). The extent of genetic diversity in Africa and the association pattern to PCa suggest that genetic and environmental exposure concurrently interpret genetic risk profiles. Unfortunately, there is limited data in Africa to support any hypothesis in this regard. The heterogeneity in risk allele frequencies, non-replication of risk variant, represents that diverse populations with African ancestry might share some common prostate cancer susceptibility alleles that may be different from the non-African populations.

Table 2 Variants from candidate gene association studies associated with PCa among Africans (January 1990–September 2020)
Full size table

Knowledge gaps, prospects, and clinical implications

The focus of research on the genetics of PCa in Africa has been the African-ancestry risk hypothesis. Therefore, available data [37, 38] provides evidence of the high-risk profile of AA from African-ancestry with unresolved issues of being black and having a first-degree relative with PCa not associated with increased PCa risk [22]. There was no evidence of pedigree or affected-sibling pair studies to understand the genetic contribution of PCa heritability in Africa. The impact of this is that most of the GWAS Consortium are largely focused on potential ancestors of AA, excluding largely the Northern, Middle, and other parts of African countries unexplored [61, 62].

There are significant individual and population-level differences in prostate cancer risk such that the inclusion of a new set of the population will result in a new ancestry-specific signal [44]. Currently, the GWAS approach identified common, low-penetrance, and shared PCa predisposing variants among the African population. These common SNPs have high penetrance (MAF of at least 5%) with modest effect sizes and explain about 12% of the genetic contribution to PCa risk [33], leaving the majority of risk unexplained. The rare variant hypothesis [63] may be substantial in this regard, which necessitates the need to go beyond the commonly used SNP arrays in GWAS. Accordingly, high-coverage targeted or whole-genome sequencing in a larger sample will provide sufficient statistical power to allow a direct variant-by-variant analysis [64].

Current efforts in the genetics of PCa have a goal towards personalized therapy for patients. Thus, important genetic epidemiological and functional studies are needed to understand the role of these variants. However, there is no consensus on the genetic architecture of Africans. In terms of individual risk profiling, the functional aspects of these variants are needed for targeted treatment programs. Thus, a wide range of genetic consortia is needed to interrogate the genomes of the African population by pooling efforts and resources.

Conclusion

The genetic architecture of PCa in Africa provides important contributions to the global understanding of PCa specifically the African-ancestry hypothesis. Although African ancestry has been successfully used to fine-mapped important variants, it only explains 30–33% of prostate cancer heritability. However, to what extent and aspects to which genetic variants explain PCa heritability in Africa are limited. Therefore, more prostate cancer consortiums are needed to justify the heritable certainties of PCa among Africans, and emphasis should be placed on the genetic epidemiological model of PCa in Africa. What we can appreciate is that the use of comprehensive methods in the search for genetic variants and functions have highlighted important candidate genes that perform a special function in PCa biology.

Availability of data and materials

Not applicable

Abbreviations

AA:

African Americans

GWAS:

Genome-wide association studies

miRNAs:

MicroRNAs

SNPs:

Single-nucleotide polymorphisms

SSA:

Sub-Saharan Africa

PCa:

Prostate cancer

References

  1. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136(5):E359–E386. https://doi.org/10.1002/ijc.29210 Epub 2014/09/16. PubMed PMID: 25220842

    Article  CAS  PubMed  Google Scholar 

  2. Adeloye D, David RA, Aderemi AV, Iseolorunkanmi A, Oyedokun A, Iweala EEJ, Omoregbe N, Ayo CK (2016) An estimate of the incidence of prostate cancer in Africa: a systematic review and meta-analysis. Plos One. 11(4):e0153496. https://doi.org/10.1371/journal.pone.0153496

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Arbyn M, Castellsagué X, de Sanjosé S, Bruni L, Saraiya M, Bray F, Ferlay J (2011) Worldwide burden of cervical cancer in 2008. Ann Oncol. 22(12):2675–2686. https://doi.org/10.1093/annonc/mdr015

    Article  CAS  PubMed  Google Scholar 

  4. Organization WH. World Health Organization cancer fact sheet. 2009.

    Google Scholar 

  5. Farmer P, Frenk J, Knaul FM, Shulman LN, Alleyne G, Armstrong L, Atun R, Blayney D, Chen L, Feachem R, Gospodarowicz M, Gralow J, Gupta S, Langer A, Lob-Levyt J, Neal C, Mbewu A, Mired D, Piot P, Reddy KS, Sachs JD, Sarhan M, Seffrin JR (2010) Expansion of cancer care and control in countries of low and middle income: a call to action. Lancet. 376(9747):1186–1193. https://doi.org/10.1016/S0140-6736(10)61152-X

    Article  PubMed  Google Scholar 

  6. Taitt HE (2018) Global trends and prostate cancer: a review of incidence, detection, and mortality as influenced by race, ethnicity, and geographic location. Am J Men’s Health. 12(6):1807–1823. https://doi.org/10.1177/1557988318798279

    Article  Google Scholar 

  7. Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C et al (2012) Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. lancet. 380(9859):2197–2223. https://doi.org/10.1016/S0140-6736(12)61689-4

    Article  PubMed  Google Scholar 

  8. Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, Abraham J, Adair T, Aggarwal R, Ahn SY, AlMazroa MA, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Barker-Collo S, Bartels DH, Bell ML, Benjamin EJ, Bennett D, Bhalla K, Bikbov B, Abdulhak AB, Birbeck G, Blyth F, Bolliger I, Boufous S, Bucello C, Burch M, Burney P, Carapetis J, Chen H, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, de Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahodwala N, de Leo D, Degenhardt L, Delossantos A, Denenberg J, Des Jarlais DC, Dharmaratne SD, Dorsey ER, Driscoll T, Duber H, Ebel B, Erwin PJ, Espindola P, Ezzati M, Feigin V, Flaxman AD, Forouzanfar MH, Fowkes FGR, Franklin R, Fransen M, Freeman MK, Gabriel SE, Gakidou E, Gaspari F, Gillum RF, Gonzalez-Medina D, Halasa YA, Haring D, Harrison JE, Havmoeller R, Hay RJ, Hoen B, Hotez PJ, Hoy D, Jacobsen KH, James SL, Jasrasaria R, Jayaraman S, Johns N, Karthikeyan G, Kassebaum N, Keren A, Khoo JP, Knowlton LM, Kobusingye O, Koranteng A, Krishnamurthi R, Lipnick M, Lipshultz SE, Ohno SL, Mabweijano J, MacIntyre MF, Mallinger L, March L, Marks GB, Marks R, Matsumori A, Matzopoulos R, Mayosi BM, McAnulty JH, McDermott MM, McGrath J, Memish ZA, Mensah GA, Merriman TR, Michaud C, Miller M, Miller TR, Mock C, Mocumbi AO, Mokdad AA, Moran A, Mulholland K, Nair MN, Naldi L, Narayan KMV, Nasseri K, Norman P, O'Donnell M, Omer SB, Ortblad K, Osborne R, Ozgediz D, Pahari B, Pandian JD, Rivero AP, Padilla RP, Perez-Ruiz F, Perico N, Phillips D, Pierce K, Pope CA III, Porrini E, Pourmalek F, Raju M, Ranganathan D, Rehm JT, Rein DB, Remuzzi G, Rivara FP, Roberts T, de León FR, Rosenfeld LC, Rushton L, Sacco RL, Salomon JA, Sampson U, Sanman E, Schwebel DC, Segui-Gomez M, Shepard DS, Singh D, Singleton J, Sliwa K, Smith E, Steer A, Taylor JA, Thomas B, Tleyjeh IM, Towbin JA, Truelsen T, Undurraga EA, Venketasubramanian N, Vijayakumar L, Vos T, Wagner GR, Wang M, Wang W, Watt K, Weinstock MA, Weintraub R, Wilkinson JD, Woolf AD, Wulf S, Yeh PH, Yip P, Zabetian A, Zheng ZJ, Lopez AD, Murray CJL (2012) Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 380(9859):2095–2128. https://doi.org/10.1016/S0140-6736(12)61728-0

    Article  PubMed  Google Scholar 

  9. Chu LW, Ritchey J, Devesa SS, Quraishi SM, Zhang H, Hsing AW (2011) Prostate cancer incidence rates in Africa. Prostate Cancer 2011:947870. Epub 2011/08/01, PubMed PMID: 22111004. https://doi.org/10.1155/2011/947870

    Article  PubMed  PubMed Central  Google Scholar 

  10. Egue M, Gnangnon FHR, Akele-Akpo MT, Maxwell PD (2019) Cancer incidence in Cotonou (Benin), 2014-2016: first results from the Cancer Registry of Cotonou. Cancer Epidemiol. 59:46–50. https://doi.org/10.1016/j.canep.2019.01.006 Epub 2019/01/28. PubMed PMID: 30685574

    Article  PubMed  Google Scholar 

  11. Medhin LB, Achila OO, Syum BE, Gebremichael KH, Said SM, Lobeck H et al (2020) Incidence of prostate cancer in Eritrea: data from the National Health Laboratory, Orotta Referral Hospital and Sembel Hospital 2011-2018. Plos One 15(4):e0232091. https://doi.org/10.1371/journal.pone.0232091 Epub 2020/04/24. PubMed PMID: 32324838; PubMed Central PMCID: PMCPMC7179877

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Carrilho C, Fontes F, Tulsidás S, Lorenzoni C, Ferro J, Brandão M, Ferro A, Lunet N (2019) Cancer incidence in Mozambique in 2015-2016: data from the Maputo Central Hospital Cancer Registry. Eur J Cancer Prev. 28(4):373–376. https://doi.org/10.1097/cej.0000000000000457 Epub 2018/06/26. PubMed PMID: 29939861

    Article  PubMed  Google Scholar 

  13. Okongo F, Ogwang DM, Liu B, Maxwell PD (2019) Cancer incidence in Northern Uganda (2013-2016). Int J Cancer. 144(12):2985–2991. https://doi.org/10.1002/ijc.32053 Epub 2018/12/12. PubMed PMID: 30536374

    Article  CAS  PubMed  Google Scholar 

  14. Koon Sun Pat M, Manraj M, Fauzee J, Sewsurn S, Parkin DM, Manraj S (2019) Trends in cancer incidence in the Republic of Mauritius, 1991–2015. Cancer Epidemiol 63:101616. https://doi.org/10.1016/j.canep.2019.101616

    Article  PubMed  Google Scholar 

  15. Elidrissi Errahhali M, Elidrissi Errahhali M, Ouarzane M, Boulouiz R, Bellaoui M (2017) Cancer incidence in eastern Morocco: cancer patterns and incidence trends, 2005-2012. BMC Cancer 17(1):587. https://doi.org/10.1186/s12885-017-3597-6 PubMed PMID: 28851324

    Article  PubMed  PubMed Central  Google Scholar 

  16. Lichtenstein P, Holm NV, Verkasalo PK, Iliadou A, Kaprio J, Koskenvuo M, Pukkala E, Skytthe A, Hemminki K (2000) Environmental and heritable factors in the causation of cancer—analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 343(2):78–85. https://doi.org/10.1056/NEJM200007133430201

    Article  CAS  PubMed  Google Scholar 

  17. Hjelmborg JB, Scheike T, Holst K, Skytthe A, Penney KL, Graff RE, Pukkala E, Christensen K, Adami HO, Holm NV, Nuttall E, Hansen S, Hartman M, Czene K, Harris JR, Kaprio J, Mucci LA (2014) The heritability of prostate cancer in the Nordic Twin Study of Cancer. Cancer Epidemiol Prev Biomark 23(11):2303–2310. https://doi.org/10.1158/1055-9965.EPI-13-0568

    Article  Google Scholar 

  18. Verhage BA, Aben KK, Witjes JA, Straatman H, Schalken JA, Kiemeney LA (2004) Site-specific familial aggregation of prostate cancer. Int J Cancer. 109(4):611–617. https://doi.org/10.1002/ijc.20015

    Article  CAS  PubMed  Google Scholar 

  19. Mucci LA, Hjelmborg JB, Harris JR, Czene K, Havelick DJ, Scheike T, Graff RE, Holst K, Möller S, Unger RH, McIntosh C, Nuttall E, Brandt I, Penney KL, Hartman M, Kraft P, Parmigiani G, Christensen K, Koskenvuo M, Holm NV, Heikkilä K, Pukkala E, Skytthe A, Adami HO, Kaprio J, for the Nordic Twin Study of Cancer (NorTwinCan) Collaboration (2016) Familial risk and heritability of cancer among twins in Nordic countries. JAMA. 315(1):68–76. https://doi.org/10.1001/jama.2015.17703

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Rebbeck TR (2017) Prostate cancer genetics: variation by race, ethnicity, and geography. Semin Radiat Oncol 27(1):3–10. https://doi.org/10.1016/j.semradonc.2016.08.002

    Article  PubMed  Google Scholar 

  21. Eeles R, Goh C, Castro E, Bancroft E, Guy M, Al Olama AA et al (2014) The genetic epidemiology of prostate cancer and its clinical implications. Nat Rev Urol. 11(1):18–31. https://doi.org/10.1038/nrurol.2013.266

    Article  CAS  PubMed  Google Scholar 

  22. Fall B, Ze ondo C, Sarr A, Ouedraogo B, Sow Y, Thiam A et al (2015) Détection précoce du cancer de la prostate chez des apparentés de premier degré au Sénégal. Afr J Urol 21(4):225–229. https://doi.org/10.1016/j.afju.2015.08.002

    Article  Google Scholar 

  23. Nemesure B, Wu S-Y, Hennis A, Leske MC (2013) Family history of prostate cancer in a black population. J Immigr Minor Health. 15(6):1107–1112. https://doi.org/10.1007/s10903-012-9710-7 PubMed PMID: 22936456

    Article  PubMed  Google Scholar 

  24. Hayes RB, Liff JM, Pottern LM, Greenberg RS, Schoenberg JB, Schwartz AG, Swanson GM, Silverman DT, Brown LM, Hoover RN, Fralmeni JF Jr (1995) Prostate cancer risk in US blacks and whites with a family history of cancer. Int J Cancer. 60(3):361–364. https://doi.org/10.1002/ijc.2910600315

    Article  CAS  PubMed  Google Scholar 

  25. Whittemore AS, Wu AH, Kolonel LN, John EM, Gallagher RP, Howe GR, West DW, Teh CZ, Stamey T (1995) Family history and prostate cancer risk in black, white, and Asian men in the United States and Canada. Am J Epidemiol. 141(8):732–740. https://doi.org/10.1093/oxfordjournals.aje.a117495

    Article  CAS  PubMed  Google Scholar 

  26. Sanderson M, Coker AL, Logan P, Zheng W, Fadden MK (2004) Lifestyle and prostate cancer among older African-American and Caucasian men in South Carolina. Cancer Causes Control. 15(7):647–655. https://doi.org/10.1023/B:CACO.0000036172.63845.d4

    Article  PubMed  PubMed Central  Google Scholar 

  27. Petersen DC, Jaratlerdsiri W, van Wyk A, Chan EKF, Fernandez P, Lyons RJ et al (2019) African KhoeSan ancestry linked to high-risk prostate cancer. BMC Med Genomics 12(1):82. https://doi.org/10.1186/s12920-019-0537-0 PubMed PMID: 31164124

    Article  PubMed  PubMed Central  Google Scholar 

  28. Stefflova K, Dulik MC, Barnholtz-Sloan JS, Pai AA, Walker AH, Rebbeck TR (2011) Dissecting the within-Africa ancestry of populations of African descent in the Americas. Plos one. 6(1):e14495. https://doi.org/10.1371/journal.pone.0014495

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Murphy AB, Ukoli F, Freeman V, Bennett F, Aiken W, Tulloch T, Coard K, Angwafo F, Kittles RA (2012) 8q24 risk alleles in West African and Caribbean men. Prostate. 72(12):1366–1373. https://doi.org/10.1002/pros.22486

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Haiman CA, Patterson N, Freedman ML, Myers SR, Pike MC, Waliszewska A, Neubauer J, Tandon A, Schirmer C, McDonald GJ, Greenway SC, Stram DO, le Marchand L, Kolonel LN, Frasco M, Wong D, Pooler LC, Ardlie K, Oakley-Girvan I, Whittemore AS, Cooney KA, John EM, Ingles SA, Altshuler D, Henderson BE, Reich D (2007) Multiple regions within 8q24 independently affect risk for prostate cancer. Nat Genet. 39(5):638–644. https://doi.org/10.1038/ng2015

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Han Y, Rand KA, Hazelett DJ, Ingles SA, Kittles RA, Strom SS et al (2016) Prostate cancer susceptibility in men of African ancestry at 8q24. J Natl Cancer Inst 108(7). https://doi.org/10.1093/jnci/djv431 Epub 2016/01/30, PubMed PMID: 26823525; PubMed Central PMCID: PMCPMC4948565

  32. Chung CC, Hsing AW, Yeboah E, Biritwum R, Tettey Y, Adjei A, Cook MB, de Marzo A, Netto G, Tay E, Boland JF, Yeager M, Chanock SJ (2014) A comprehensive resequence-analysis of 250 kb region of 8q24. 21 in men of African ancestry. Prostate. 74(6):579–589. https://doi.org/10.1002/pros.22726

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Du Z, Lubmawa A, Gundell S, Wan P, Nalukenge C, Muwanga P et al (2018) Genetic risk of prostate cancer in Ugandan men. Prostate. 78(5):370–376. https://doi.org/10.1002/pros.23481

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Fernandez P, Salie M, du Toit D, van der Merwe A (2015) Analysis of prostate cancer susceptibility variants in South African men: replicating associations on chromosomes 8q24 and 10q11. Prostate Cancer. 2015:465184–465186. https://doi.org/10.1155/2015/465184

    Article  PubMed  PubMed Central  Google Scholar 

  35. Ahmadiyeh N, Pomerantz MM, Grisanzio C, Herman P, Jia L, Almendro V, He HH, Brown M, Liu XS, Davis M, Caswell JL, Beckwith CA, Hills A, MacConaill L, Coetzee GA, Regan MM, Freedman ML (2010) 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC. Proc Natl Acad Sci. 107(21):9742–9746. https://doi.org/10.1073/pnas.0910668107

    Article  PubMed  Google Scholar 

  36. Pomerantz MM, Beckwith CA, Regan MM, Wyman SK, Petrovics G, Chen Y, Hawksworth DJ, Schumacher FR, Mucci L, Penney KL, Stampfer MJ, Chan JA, Ardlie KG, Fritz BR, Parkin RK, Lin DW, Dyke M, Herman P, Lee S, Oh WK, Kantoff PW, Tewari M, McLeod DG, Srivastava S, Freedman ML (2009) Evaluation of the 8q24 prostate cancer risk locus and MYC expression. Cancer Res. 69(13):5568–5574. https://doi.org/10.1158/0008-5472.CAN-09-0387

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Cook MB, Wang Z, Yeboah ED, Tettey Y, Biritwum RB, Adjei AA, Tay E, Truelove A, Niwa S, Chung CC, Chokkalingam AP, Chu LW, Yeager M, Hutchinson A, Yu K, Rand KA, Haiman CA, Hoover RN, Hsing AW, Chanock SJ, Consortium AAPCG. A genome-wide association study of prostate cancer in West African men. Hum Genet. 2014;133(5):509–21.

  38. Cook MB, Wang Z, Yeboah ED, Tettey Y, Biritwum RB, Adjei AA et al (2014) A genome-wide association study of prostate cancer in West African men. Human Genet. 133(5):509–521. https://doi.org/10.1007/s00439-013-1387-z

    Article  CAS  Google Scholar 

  39. Conti DV, Wang K, Sheng X, Bensen JT, Hazelett DJ, Cook MB et al (2017) Two novel susceptibility loci for prostate cancer in men of African ancestry. J Natl Cancer Inst 109(8). https://doi.org/10.1093/jnci/djx084 Epub 2017/11/09. PubMed PMID: 29117387; PubMed Central PMCID: PMCPMC5448553

  40. Akamatsu S, Takata R, Haiman CA, Takahashi A, Inoue T, Kubo M, Furihata M, Kamatani N, Inazawa J, Chen GK, le Marchand L, Kolonel LN, Katoh T, Yamano Y, Yamakado M, Takahashi H, Yamada H, Egawa S, Fujioka T, Henderson BE, Habuchi T, Ogawa O, Nakamura Y, Nakagawa H (2012) Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese. Nat Genet. 44(4):426–429. https://doi.org/10.1038/ng.1104

    Article  CAS  PubMed  Google Scholar 

  41. Du M, Tillmans L, Gao J, Gao P, Yuan T, Dittmar RL et al (2016) Chromatin interactions and candidate genes at ten prostate cancer risk loci. Sci Rep. 6(1):1–13

    Article  Google Scholar 

  42. Kote-Jarai Z, Al Olama AA, Giles GG, Severi G, Schleutker J, Weischer M et al (2011) Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Nat Genet. 43(8):785–791. https://doi.org/10.1038/ng.882

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Sun J, Zheng SL, Wiklund F, Isaacs SD, Li G, Wiley KE, Kim ST, Zhu Y, Zhang Z, Hsu FC, Turner AR, Stattin P, Liu W, Kim JW, Duggan D, Carpten J, Isaacs W, Grönberg H, Xu J, Chang BL (2009) Sequence variants at 22q13 are associated with prostate cancer risk. Cancer Res. 69(1):10–15. https://doi.org/10.1158/0008-5472.CAN-08-3464 PubMed PMID: 19117981

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Harlemon M, Ajayi O, Kachambwa P, Kim MS, Simonti CN, Quiver MH, Petersen DC, Mittal A, Fernandez PW, Hsing AW, Baichoo S. A custom genotyping array reveals population-level heterogeneity for the genetic risks of prostate cancer and other cancers in Africa. Cancer research. 2020;80(13):2956–66.

  45. Haiman CA, Chen GK, Blot WJ, Strom SS, Berndt SI, Kittles RA, Rybicki BA, Isaacs WB, Ingles SA, Stanford JL, Diver WR, Witte JS, Hsing AW, Nemesure B, Rebbeck TR, Cooney KA, Xu J, Kibel AS, Hu JJ, John EM, Gueye SM, Watya S, Signorello LB, Hayes RB, Wang Z, Yeboah E, Tettey Y, Cai Q, Kolb S, Ostrander EA, Zeigler-Johnson C, Yamamura Y, Neslund-Dudas C, Haslag-Minoff J, Wu W, Thomas V, Allen GO, Murphy A, Chang BL, Zheng SL, Leske MC, Wu SY, Ray AM, Hennis AJM, Thun MJ, Carpten J, Casey G, Carter EN, Duarte ER, Xia LY, Sheng X, Wan P, Pooler LC, Cheng I, Monroe KR, Schumacher F, le Marchand L, Kolonel LN, Chanock SJ, Berg DVD, Stram DO, Henderson BE (2011) Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21. Nat Genet. 43(6):570–573. https://doi.org/10.1038/ng.839 Epub 2011/05/22, PubMed PMID: 21602798

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Fernandez P, De Beer P, Van der Merwe L, Heyns C (2010) Genetic variations in androgen metabolism genes and associations with prostate cancer in South African men. South Afr Med J. 100(11):741–745. https://doi.org/10.7196/SAMJ.4104

    Article  CAS  Google Scholar 

  47. Souiden Y, Mahdouani M, Chaieb K, Elkamel R, Mahdouani K (2011) CYP17 gene polymorphism and prostate cancer susceptibility in a Tunisian population. Cancer epidemiology. 35(5):480–484. https://doi.org/10.1016/j.canep.2010.11.008

    Article  CAS  PubMed  Google Scholar 

  48. Souiden Y, Mahdouani M, Chaieb K, Bakhrouf A, Mahdouani K (2012) Lack of association of CYP1A1 polymorphism with prostate cancer susceptibility of Tunisian men. Genet Testing Mol Biomark. 16(7):661–666. https://doi.org/10.1089/gtmb.2011.0212

    Article  CAS  Google Scholar 

  49. Fernandez P, Zeigler-Johnson CM, Spangler E, van der Merwe A, Jalloh M, Gueye SM, Rebbeck TR (2012) Androgen metabolism gene polymorphisms, associations with prostate cancer risk and pathological characteristics: a comparative analysis between South African and Senegalese men. Prostate Cancer. 2012:1–8. https://doi.org/10.1155/2012/798634

    Article  CAS  Google Scholar 

  50. Taioli E, Sears V, Watson A, Flores-Obando RE, Jackson MD, Ukoli FA, de Syllos Cólus IM, Fernandez P, McFarlane-Anderson N, Ostrander EA, Rodrigues IS, Stanford JL, Taylor JA, Tulloch-Reid M, Ragin CCR (2013) Polymorphisms in CYP17 and CYP3A4 and prostate cancer in men of African descent. Prostate. 73(6):668–676. https://doi.org/10.1002/pros.22612

    Article  CAS  PubMed  Google Scholar 

  51. Apolonia NV, Lorca AR, Alonso MG, Bahri R, Harich N, Cuenca DS, Esteban ME, Santander AF. Genetic diversity of CYP3A4 and CYP3A5 polymorphisms in North African populations: data from Morocco and Tunisia. London: SAGE Publications Sage UK; 2015.

  52. Brureau L, Moningo D, Emeville E, Ferdinand S, Punga A, Lufuma S, Blanchet P, Romana M, Multigner L (2016) Polymorphisms of estrogen metabolism-related genes and prostate cancer risk in two populations of African ancestry. Plos One. 11(4):e0153609. https://doi.org/10.1371/journal.pone.0153609

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Fernandez P, de Beer PM, van der Merwe L, Heyns CF (2008) COX-2 promoter polymorphisms and the association with prostate cancer risk in South African men. Carcinogenesis. 29(12):2347–2350. https://doi.org/10.1093/carcin/bgn245

    Article  CAS  PubMed  Google Scholar 

  54. Fawzy MS, Elfayoumi A-R, Mohamed RH, Fatah IRA, Saadawy SF (2016) Cyclooxygenase 2 (rs2745557) polymorphism and the susceptibility to benign prostate hyperplasia and prostate cancer in Egyptians. Biochem Genet. 54(3):326–336. https://doi.org/10.1007/s10528-016-9722-4

    Article  CAS  PubMed  Google Scholar 

  55. Souiden Y, Mahdouani M, Chaieb K, Elkamel R, Mahdouani K (2010) Polymorphisms of glutathione-S-transferase M1 and T1 and prostate cancer risk in a Tunisian population. Cancer Epidemiol. 34(5):598–603. https://doi.org/10.1016/j.canep.2010.06.002

    Article  CAS  PubMed  Google Scholar 

  56. Benabdelkrim M, Djeffal O, Berredjem H (2018) GSTM1 and GSTT1 polymorphisms and susceptibility to prostate cancer: a case-control study of the Algerian population. Asian Pac J Cancer Prev 19(10):2853–2858. https://doi.org/10.22034/APJCP.2018.19.10.2853

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Said R, Bougatef K, Boubaker NS, Jenni R, Derouiche A, Chebil M et al (2019) Polymorphisms in XPC gene and risk for prostate cancer. Mol Biol Rep. 46(1):1117–1125. https://doi.org/10.1007/s11033-018-4572-2

    Article  CAS  PubMed  Google Scholar 

  58. Djomkam ALZ, Beyeme Sala T, Baari Memba C, Njimoh DL (2019) Prevalence of the Ser217Leu variant of the ELAC2 gene and its association with prostate cancer in population of the Littoral region of Cameroon. Prostate Cancer. 2019:1–6. https://doi.org/10.1155/2019/5974928

    Article  CAS  Google Scholar 

  59. Akinloye O, Gromoll J, Simoni M (2011) Variation in CAG and GGN repeat lengths and CAG/GGN haplotype in androgen receptor gene polymorphism and prostate carcinoma in Nigerians. Br J Biom Sci. 68(3):138–142. https://doi.org/10.1080/09674845.2011.11730341

    Article  CAS  Google Scholar 

  60. Sfar S, Saad H, Mosbah F, Chouchane L (2008) Association of HSP70-hom genetic variant with prostate cancer risk. Mol Biol Rep. 35(3):459–464. https://doi.org/10.1007/s11033-007-9107-1

    Article  CAS  PubMed  Google Scholar 

  61. de Vries J, Munung SN, Matimba A, McCurdy S, Oukem-Boyer OOM, Staunton C et al (2017) Regulation of genomic and biobanking research in Africa: a content analysis of ethics guidelines, policies and procedures from 22 African countries. BMC Med Ethics. 18(1):1–9

    Article  Google Scholar 

  62. Ayuku S (2017) Establishing a Cancer Research Consortium in low-and middle-income countries: challenges faced and lessons learned

    Google Scholar 

  63. Zhang Q (2015) Associating rare genetic variants with human diseases. Front Genet. 6:133

    Article  Google Scholar 

  64. Wu X, Gu J (2016) Heritability of prostate cancer: a tale of rare variants and common single nucleotide polymorphisms. Ann Transl Med 4:206. https://doi.org/10.21037/atm.2016.05.31

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

None

Funding

No funding was obtained for this study.

Author information

Authors and Affiliations

  1. Department of Molecular Medicine, College of Health Sciences, School of Medical Science, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana

    Emmanuel Acheampong, Evans Asamoah Adu, Christian Obirikorang, Emmanuella Nsenbah Acheampong & Francis Agyemang Yeboah

  2. School of Medical and Health Science, Edith Cowan University, Joondalup, Australia

    Emmanuel Acheampong & Enoch Odame Anto

  3. Urology Unit, Department of Surgery, Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana

    George Amoah & Christian Kofi Gyasi-Sarpong

  4. Department of Pathology, Police Hospital, Accra, Ghana

    Osei Owusu Afriyie

  5. Department of Pathology, Komfo Anokye Teaching Hospital, Kumasi, Ghana

    Osei Owusu Afriyie

  6. Department of Surgery, Komfo Anokye Teaching Hospital, Kumasi, Ghana

    Joseph Yorke

  7. Department of Medical Diagnostics, Faculty of Allied Health Sciences, KNUST, Kumasi, Ghana

    Enoch Odame Anto & Michael Adu Gyamfi

Authors
  1. Emmanuel Acheampong
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Evans Asamoah Adu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Christian Obirikorang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. George Amoah
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Osei Owusu Afriyie
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Joseph Yorke
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Enoch Odame Anto
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Michael Adu Gyamfi
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Emmanuella Nsenbah Acheampong
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Christian Kofi Gyasi-Sarpong
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Francis Agyemang Yeboah
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

EA and EAA: conception and methodology; EA and EAA: data curation, inclusion, and exclusion criteria. EA and EAA: original draft; EA, EAA, EOA, GA, MAG, ENA, CKSG, FAY, OAA, JY, and CO: writing and editing; supervision: CKSG, FAY, and CO. The authors read and approved the final manuscript.

Corresponding author

Correspondence to Emmanuel Acheampong.

Ethics declarations

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Acheampong, E., Adu, E.A., Obirikorang, C. et al. Association of genetic variants with prostate cancer in Africa: a concise review. Egypt J Med Hum Genet 22, 33 (2021). https://doi.org/10.1186/s43042-021-00157-w

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1186/s43042-021-00157-w

Keywords