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Egyptian Journal of Medical Human Genetics
Fig. 2 | Egyptian Journal of Medical Human Genetics

Fig. 2

From: In silico investigations on curcuminoids from Curcuma longa as positive regulators of the Wnt/β-catenin signaling pathway in wound healing

Fig. 2

Wnt proteins bind to Frizzled (Fz) and LRP-5, Axin is recruited to the membranes. The interaction between Axin and LRP-5 may prevent Axin from participating in the degradation of β-catenin. Dvl may also receive signals from the Fz/LRP complex, resulting in the inhibition of GSK3B. β-catenin is not degraded, which eventually leads to transcription of the Wnt-targeted gene, which results in the following events like cell division, cell proliferation, and cell migration to the wound site

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