Table 6 Comparison between WT1 genotyping and hMICL expression to basal laboratory data of AML patients
Parameters (M ± SD) | WT1 (N = 63) | P value | HMICL (N = 63) | P value | ||
|---|---|---|---|---|---|---|
GG + AG (N = 17) | AA (N = 46) | Negative (N = 8) | Positive (N = 55) | |||
Age | 49.1 ± 16.5 | 47.5 ± 14.1 | 0.719 | 54.4 ± 17.8 | 47.0 ± 14.0 | 0.292 |
TLC | 47.1 ± 45.9 | 56.2 ± 54.3 | 0.951 | 64.0 ± 61.0 | 54.0 ± 50.0 | 0.408 |
HB | 8.1 ± 1.8 | 7.7 ± 1.6 | 0.477 | 7.6 ± 1.6 | 7.8 ± 1.7 | 0.758 |
Platelets | 92.5 ± 60.9 | 81.2 ± 72.5 | 0.654 | 87.3 ± 73.1 | 75.2 ± 66.7 | 0.680 |
Blast count | 63.6 ± 22.7 | 57.9 ± 24.3 | 0.392 | 75.7 ± 17.2 | 57.1 ± 23.8 | 0.020 |
LDH | 882 ± 714 | 600 ± 564 | 0.154 | 927 ± 873 | 647 ± 563 | 0.522 |
ALT | 29.6 ± 15.8 | 31.8 ± 18.4 | 0.649 | 35.8 ± 16.3 | 30.5 ± 17.8 | 0.415 |
AST | 23.3 ± 7.9 | 27.4 ± 13.1 | 0.148 | 23.5 ± 10.2 | 26.7 ± 12.3 | 0.439 |
Creatinine | 1.4 ± 0 .9 | 1.7 ± 1.5 | 0.414 | 1.1 ± 0.8 | 1.7 ± 1.4 | 0.142 |
BUN | 26.8 ± 13.7 | 33.3 ± 22.6 | 0.168 | 24.3 ± 13.0 | 32.6 ± 21.4 | 0.154 |
Survival (months) | 18.9 ± 4.6 | 7.1 ± 5.7 | 0.000 | 21.8 ± 2.0 | 8.6 ± 6.5 | 0.001 |