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Table 3 Top 20 upstream regulators revealed by Ingenuity Pathway Analysis

From: Pathway analysis of smoking-induced changes in buccal mucosal gene expression

Upstream regulator Molecule type Log2 ratio p value Z score
TP53 Transcription regulator 0.477 1.39 × 10–09 1.028
Dexamethasone Chemical drug 1.10 × 10–06 0.438
APP Other 1.709 1.39 × 10–06 0.01
SMAD3 Transcription regulator 0.687 3.20 × 10–06 − 1.508
TNF Cytokine 0.098 5.90 × 10–06 − 1.169
Decitabine Chemical drug 6.61 × 10–06 1.433
Tetradecanoylphorbol Chemical drug 8.14 × 10–06 − 1.916
L-type calcium channel Complex 1.01 × 10–05 − 1.98
Camptothecin Chemical drug 1.53 × 10–05 − 0.64
KDM5B Transcription regulator 0.95 1.79 × 10–05 1.04
OSM Cytokine − 0.844 2.74 × 10–05 1.01
TGFB3 Growth factor 0.488 2.80 × 10–05 − 0.877
Nitrofurantoin Chemical drug 2.90 × 10–05 − 1.437
Forskolin Chemical toxicant 4.11 × 10–05 − 2.25
TP63 Transcription regulator 1.346 4.15 × 10–05 − 2.611
CSF3 Cytokine 0.301 6.00 × 10–05 − 0.494
PPARA Ligand-dependent nuclear receptor 0.147 6.01 × 10–05 − 0.789
Haloperidol Chemical drug 6.35 × 10–05 − 1.591
LY294002 Chemical-kinase inhibitor 7.53 × 10–05 0.822
RASSF1 Other 0.33 8.26 × 10–05 0.333