Table 3 Top 20 upstream regulators revealed by Ingenuity Pathway Analysis
From: Pathway analysis of smoking-induced changes in buccal mucosal gene expression
Upstream regulator | Molecule type | Log2 ratio | p value | Z score |
|---|---|---|---|---|
TP53 | Transcription regulator | 0.477 | 1.39 × 10–09 | 1.028 |
Dexamethasone | Chemical drug | – | 1.10 × 10–06 | 0.438 |
APP | Other | 1.709 | 1.39 × 10–06 | 0.01 |
SMAD3 | Transcription regulator | 0.687 | 3.20 × 10–06 | − 1.508 |
TNF | Cytokine | 0.098 | 5.90 × 10–06 | − 1.169 |
Decitabine | Chemical drug | – | 6.61 × 10–06 | 1.433 |
Tetradecanoylphorbol | Chemical drug | – | 8.14 × 10–06 | − 1.916 |
L-type calcium channel | Complex | – | 1.01 × 10–05 | − 1.98 |
Camptothecin | Chemical drug | – | 1.53 × 10–05 | − 0.64 |
KDM5B | Transcription regulator | 0.95 | 1.79 × 10–05 | 1.04 |
OSM | Cytokine | − 0.844 | 2.74 × 10–05 | 1.01 |
TGFB3 | Growth factor | 0.488 | 2.80 × 10–05 | − 0.877 |
Nitrofurantoin | Chemical drug | – | 2.90 × 10–05 | − 1.437 |
Forskolin | Chemical toxicant | – | 4.11 × 10–05 | − 2.25 |
TP63 | Transcription regulator | 1.346 | 4.15 × 10–05 | − 2.611 |
CSF3 | Cytokine | 0.301 | 6.00 × 10–05 | − 0.494 |
PPARA | Ligand-dependent nuclear receptor | 0.147 | 6.01 × 10–05 | − 0.789 |
Haloperidol | Chemical drug | – | 6.35 × 10–05 | − 1.591 |
LY294002 | Chemical-kinase inhibitor | – | 7.53 × 10–05 | 0.822 |
RASSF1 | Other | 0.33 | 8.26 × 10–05 | 0.333 |