Table 3 Summary of main studies about CFTR and lung diseases
From: Cystic fibrosis transmembrane conductance regulator (CFTR): beyond cystic fibrosis
Authors | Setting | Sample size | Major findings |
|---|---|---|---|
Raju et al | Review | Cigarette smoke induces acquired CFTR dysfunction with impaired mucociliary clearance through acrolein, cadmium and arsenic COPD patients shows reduced CFTR with also pathological systemic consequences | |
Nielsen et al. [65] | Meta-analysis | 15 studies 2.113 asthma cases 13.457 controls | Heterozygous CF carriers have higher risk for asthma (OR 1.61, 1.18–2.21) |