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Table 6 Haplotype analysis on association of MTHFR 677C > T; MTRR 66A > G; MTR 2756A > G; AGT 704T > C; and VEGFA 634C > G with FGR risk

From: Association of maternal genetic polymorphisms with fetal growth restriction syndrome in Russian pregnant women from Rostov region

Haplotype (Alleles)

Frequencies

OR (95%CI)

P values

Total

FGR

Controls

MTHFR 677T * MTRR 66A

0.1

0.05

0.14

4.66 (1.21–17.87)

0.027**

MTRR 66G * AGT 704T

0.21

0.31

0.12

0.27 (0.08–0.89)

0.034*

MTR 2756G * VEGFA 634C

0.05

0

0.1

 > 20

 < 0.0001**

AGT 704T * VEGFA 634G

0.24

0.32

0.18

0.31 (0.12–0.84)

0.023*

  1. *Decreased FGR risk
  2. **Increased FGR risk