Wu Y, Ding Y, Tanaka Y, Zhang W (2014) Risk factors contributing to type 2 diabetes and recent advances in the treatment and prevention. Int J Med Sci 11:1185–1200. https://doi.org/10.7150/ijms.10001
Article
PubMed
PubMed Central
Google Scholar
Fan W (2017) Epidemiology in diabetes mellitus and cardiovascular disease. Cardiovasc Endocrinol 16:8–16. https://doi.org/10.1097/XCE.0000000000000116
Article
Google Scholar
Shi Y, Hu FB (2014) The global implications of diabetes and cancer. Lancet 383:1947–1948. https://doi.org/10.1016/S0140-6736(14)60886-2
Article
PubMed
Google Scholar
Caballero AE, Ceriello A, Misra A, Aschner P, McDonnell ME, Hassanein M, Ji L, Mbanya JC, Fonseca VA (2020) COVID-19 in people living with diabetes: an international consensus. J Diabetes Complications 9:107671. https://doi.org/10.1016/j.jdiacomp.2020.107671
Article
Google Scholar
Amira REB, Samy AH, Abeer AA, Yehia AH, Tarek MM (2016) Saponins and their potential role in diabetes mellitus. Diabetes Manag 7(148–1):5
Google Scholar
Elekofehinti OO, Onunkun AT, Olaleye TM (2020) Cymbopogon citratus (DC.) Stapf mitigates ER-stress induced by streptozotocin in rats via down-regulation of GRP78 and up-regulation of Nrf2 signaling. J Ethnopharmacol 262:113–130
Article
Google Scholar
Nelson DL, Cox MM (2008) Lehninger principles of biochemistry, 5 edn. W. H. Freeman, New York
Brand MD, Orr AL, Perevoshchikova IV, Quinlan CL (2013) The role of mitochondrial function and cellular bioenergetics in ageing and disease. Br J Dermatol 69:1–8. https://doi.org/10.1111/bjd.12208
Article
CAS
Google Scholar
Bertholet AM, Delerue T, Millet AM, Moulis MF, David C, Daloyau M et al (2016) Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity. Neurobiol Dis 90:3–19
Article
CAS
PubMed
Google Scholar
Mishra P, Chan DC (2016) Metabolic regulation of mitochondrial dynamics. J Cell Biol 4:379–87. https://doi.org/10.1083/jcb.201511036
Article
CAS
Google Scholar
Fang WJ, Wang CJ, He Y, Zhou YL, Peng XD, Liu SK (2017) Resveratrol alleviates diabetic cardiomyopathy in rats by improving mitochondrial function through PGC-1α deacetylation. Acta Pharmacol Sin 1:59–73. https://doi.org/10.1038/aps.2017.50
Article
CAS
Google Scholar
Villena JA (2015) New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond. FEBS J 4:647–672. https://doi.org/10.1111/febs.13175
Article
CAS
Google Scholar
Bogacka I, Xie H, Bray GA, Smith SR (2005) Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo. Diabetes 54:1392–1399
Article
CAS
PubMed
Google Scholar
Sergi D, Naumovski N, Heilbronn L, Abeywardena M, O’Callaghan N et al (2019) Mitochondrial (Dys) function and insulin resistance: from pathophysiological molecular mechanisms to the impact of diet. Front Physiol. https://doi.org/10.3389/fphys.2019.00532
Article
PubMed
PubMed Central
Google Scholar
Antoun G, McMurray F, Thrush AB, Patten DA, Peixoto AC, Slack RS et al (2015) Impaired mitochondrial oxidative phosphorylation and supercomplex assembly in rectus abdominis muscle of diabetic obese individuals. Diabetologia 58:2861–2866. https://doi.org/10.1007/s00125-015-3772-8
Article
CAS
PubMed
Google Scholar
Chen J, Wong HS, Leong PK, Leung HY, Chan WM, Ko KM (2017) Ursolic acid induces mitochondrial biogenesis through the activation of AMPK and PGC-1 in C2C12 myotubes: a possible mechanism underlying its beneficial effect on exercise endurance. Food Funct 7:2425–2436. https://doi.org/10.1039/c7fo00127d
Article
CAS
Google Scholar
Yuan X, Gang W, You Y, Huang Y, Lee H, Dong M, Jun L, Hu T, Zhang H, Zhang C, Zhou H, Ye R, Qi X et al (2016) Rutin ameliorates obesity through brown fat activation. FASEB J. https://doi.org/10.1096/fj.201600459RR
Article
PubMed
PubMed Central
Google Scholar
Yang K, Chen Z, Gao J, Shi W, Li L, Jiang S, Hu H, Liu Z, Xu D, Wu LH (2017) The key roles of GSK-3β in regulating mitochondrial activity. Cell Physiol Biochem 44:1445–1459. https://doi.org/10.1159/000485580
Article
CAS
PubMed
Google Scholar
Elekofehinti OO, Oyedokun VO, Iwaloye O, Lawal AO, Ejelonu OC (2021) Momordica charantia silver nanoparticles modulate S OCS/JAK/STAT and P13K/Akt/PTEN signalling pathways in the kidney of streptozotocin-induced diabetic rats. J Diabetes Metab Disord 66:1–16
Google Scholar
Akhtar N, Khan BA, Majid A, Khan S, Mahmood T, Gulfishan J et al (2011) Pharmaceutical and biopharmaceutical evaluation of extracts from different plant parts of indigenous origin for their hypoglycemic responses in rabbits. Acta Pol Pharm 6:919–925
Google Scholar
Hasan I, Khatoon S (2012) Effect of Momordica charantia (bitter gourd) tablets in diabetes mellitus: type 1 and Type 2. Prime Res Med 2:72–74
Google Scholar
Nahar MK, Zarina-Zakaria U, Fazlul-Bari MD (2015) Green synthesis of silver nanoparticles using Momordica charantia fruit extracts. Adv Mat Res. https://doi.org/10.4028/www.scientific.net/amr.1109.35
Article
Google Scholar
Abdelwahed W, Degobert G, Stainmesse S, Fessi H (2006) Freeze-drying of nanoparticles: formulation, process and storage considerations. Adv Drug Deliv Rev 58:1688–1713
Article
CAS
PubMed
Google Scholar
Oluyede DM, Lawal AO, Adebimpe MO et al (2021) Biochemical and molecular effects of naringenin on the cardiovascular oxidative and pro-inflammatory effects of oral exposure to diesel exhaust particles in rats. Air Qual Atmos Health. https://doi.org/10.1007/s11869-021-00991-2
Article
Google Scholar
Pinti MV, Fink GK, Hathaway QA, Durr AJ, Kunovac A, Hollander JM (2019) Mitochondrial dysfunction in type 2 diabetes mellitus: an organ-based analysis. Am J Physiol Endocrinol Metab 2:268–285. https://doi.org/10.1152/ajpendo.00314.2018
Article
CAS
Google Scholar
Gonzalez-Franquesa A, Patti ME (2017) Insulin resistance and mitochondrial dysfunction. Adv Exp Med Biol 982:465–520. https://doi.org/10.1007/978-3-319-55330-6_25
Article
CAS
PubMed
Google Scholar
Di Meo S, Iossa S, Venditti P (2017) Skeletal muscle insulin resistance: role of mitochondria and other ROS sources. J Endocrinol 1:15–42. https://doi.org/10.1530/JOE-16-0598
Article
Google Scholar
Jornayvaz FR, Shulman GI (2010) Regulation of mitochondrial biogenesis. Essays Biochem 47:69–84. https://doi.org/10.1042/bse0470069
Article
CAS
PubMed
Google Scholar
Sergio R, Isabel T, Iván M, Ángel L (2020) PGC-1α, inflammation, and oxidative stress: an integrative view in metabolism. Oxid Med Cell Longev. https://doi.org/10.1155/2020/1452696
Article
Google Scholar
Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM (1999) Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 1:115–124. https://doi.org/10.1016/S0092-8674(00)80611-X
Article
Google Scholar
Finck BN, Kelly DP (2006) PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J Clin Invest 16(61):5–22
Google Scholar
Handschin C, Spiegelman BM (2006) Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr Rev 27:728–735
Article
CAS
PubMed
Google Scholar
Jager S, Handschin C, St-Pierre J et al (2007) AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1 alpha. Proc Natl Acad Sci 104:12017–12022
Article
PubMed
PubMed Central
Google Scholar
Musi N, Fujii N, Hirshman MF et al (2001) AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise. Diabetes 50:921–927
Article
CAS
PubMed
Google Scholar
Bandyopadhyay GK, Yu JG, Ofrecio J et al (2006) Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects. Diabetes 55:2277–2285
Article
CAS
PubMed
Google Scholar
D’Alessandro A, El Kasmi KC, Plecitá-Hlavatá L, Ježek P, Li M, Zhang H et al (2017) Hallmarks of pulmonary hypertension: mesenchymal and inflammatory cell metabolic reprogramming. Antioxid Redox. https://doi.org/10.1089/ars.2017.7217
Article
Google Scholar
Lee TW, Bai KJ, Lee TI et al (2017) PPARs modulate cardiac metabolism and mitochondrial function in diabetes. J Biomed Sci 24:5. https://doi.org/10.1186/s12929-016-0309-5
Article
CAS
PubMed
PubMed Central
Google Scholar
Patterson AD, Shah YM, Matsubara T, Krausz KW, Gonzalez FJ (2012) PPARα-dependent induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity. Hepatol 56:281–290
Article
CAS
Google Scholar
Jang YJ, Son HJ, Choi YM, Ahn J, Jung CH, Ha TY (2017) Apigenin enhances skeletal muscle hypertrophy and myoblast differentiation by regulating Prmt7. Oncotarget 8:78300–78311. https://doi.org/10.18632/oncotarget.20962
Article
PubMed
PubMed Central
Google Scholar
Iwaloye O, Elekofehinti OO, Oluwarotimi EA et al (2020) Insight into glycogen synthase kinase-3β inhibitory activity of phyto-constituents from Melissa officinalis: in silico studies. In Silico Pharmacol 8:2. https://doi.org/10.1007/s40203-020-00054-x
Article
PubMed
PubMed Central
Google Scholar
Sun Q, Jia N, Li X, Yang J, Chen G (2019) Grape seed proanthocyanidins ameliorate neuronal oxidative damage by inhibiting GSK-3β-dependent mitochondrial permeability transition pore opening in an experimental model of sporadic Alzheimer’s disease. Aging 12:4107–4124. https://doi.org/10.18632/aging.102041
Article
Google Scholar
Mahmoud AM, Ashour MB, Abdel-Moneim A, Ahmed OM (2012) Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic rats. J Diabetes Complications 6:483–490
Article
Google Scholar
Bastard JP, Piéroni L, Hainque B (2000) Relationship between plasma plasminogen activator inhibitor 1 and insulin resistance. Diabetes Metabol Res Rev 3:92–201
Google Scholar
Chen Y, Wu Y, Yang Y et al (2018) Transcriptomic and proteomic analysis of potential therapeutic target genes in the liver of metformin-treated sprague-dawley rats with type 2 diabetes mellitus. Int J Mol Med 6:3327–3341. https://doi.org/10.3892/ijmm.2018.3535
Article
CAS
Google Scholar
Nana W, Tiegang L, Ping H (2016) The effect of tianmai xiaoke pian on insulin resistance through PI3-K/AKT signal pathway. J Diabetes Res 2016:1–8
Google Scholar
Maosheng L, Huilin L, Hengxia Z, Miao S, Deliang L (2020) Effects of hydroxysafflor yellow A on the PI3K/AKT pathway and apoptosis of pancreatic β-cells in type 2 diabetes mellitus rats. Diabetes Metab Syndr Obes 13:1097–1107. https://doi.org/10.2147/DMSO.S246381
Article
Google Scholar
Sun H, Liu X, Long SR, Wang T, Ge H, Wang Y, Yu S, Xue Y, Zhang Y, Li X, Li W (2019) Antidiabetic effects of pterostilbene through PI3K/Akt signal pathway in high fat diet and STZ induced diabetic rats. Eur J Pharmacol 59(1):72526. https://doi.org/10.1016/j.ejphar.2019.172526
Article
CAS
Google Scholar
Singh N, Gupta M, Sirohi P, Varsha S (2008) Effects of alcoholic extract of Momordica charantia. (Linn) whole fruit powder on the pancreatic islets of alloxan diabetic albino rats. J Environ Biol 29(1):101–6
CAS
PubMed
Google Scholar