Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68(6):394–424
Article
PubMed
Google Scholar
Fix OK, Hameed B, Fontana RJ, Kwok RM, McGuire BM, Mulligan DC, Pratt DS, Russo MW, Schilsky ML, Verna EC, Loomba R, Cohen DE, Bezerra JA, Reddy KR, Chung RT (2020) Clinical Best Practice Advice for Hepatology and Liver Transplant Providers During the COVID-19 Pandemic: AASLD Expert Panel Consensus Statement. Hepatology 72(1):287–304
Article
CAS
PubMed
Google Scholar
Khan FS, Ali I, Afridi UK, Ishtiaq M, Mehmood R (2017) Epigenetic mechanisms regulating the development of hepatocellular carcinoma and their promise for therapeutics. Hepatol Int 11(1):45–53
Article
PubMed
Google Scholar
Danstrup CS, Marcussen M, Pedersen IS, Jacobsen H, Dybkaer K, Gaihede M (2020) DNA methylation biomarkers in peripheral blood of patients with head and neck squamous cell carcinomas. A systematic review. PLoS ONE 15(12):e0244101
Article
CAS
PubMed
PubMed Central
Google Scholar
Calvisi DF, Ladu S, Gorden A, Farina M, Lee JS, Conner EA, Schroeder I, Factor VM, Thorgeirsson SS (2007) Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma. J Clin Invest 117(9):2713–2722
Article
CAS
PubMed
PubMed Central
Google Scholar
Vucic EA, Brown CJ, Lam WL (2008) Epigenetics of cancer progression. Pharmacogenomics 9(2):215–234
Article
CAS
PubMed
Google Scholar
Teodoridis JM, Strathdee G, Brown R (2004) Epigenetic silencing mediated by CpG island methylation: potential as a therapeutic target and as a biomarker. Drug Resist Updat 7(4–5):267–278
Article
CAS
PubMed
Google Scholar
Tian Y, Wong VW, Chan HL, Cheng AS (2013) Epigenetic regulation of hepatocellular carcinoma in non-alcoholic fatty liver disease. Semin Cancer Biol 23(6 Pt B):471–482
Article
CAS
PubMed
Google Scholar
Weng X, Wu J, Lv Z, Peng C, Chen J, Zhang C, He B, Tong R, Hu W, Ding C, Cao L, Chen D, Wu J, Zheng S (2019) Targeting Mybbp1a suppresses HCC progression via inhibiting IGF1/AKT pathway by CpG islands hypo-methylation dependent promotion of IGFBP5. EBioMedicine 44:225–236
Article
PubMed
PubMed Central
Google Scholar
Burbee DG, Forgacs E, Zochbauer-Muller S, Shivakumar L, Fong K, Gao B, Randle D, Kondo M, Virmani A, Bader S, Sekido Y, Latif F, Milchgrub S, Toyooka S, Gazdar AF, Lerman MI, Zabarovsky E, White M, Minna JD (2001) Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. J Natl Cancer Inst 93(9):691–699
Article
CAS
PubMed
Google Scholar
van der Weyden L, Tachibana KK, Gonzalez MA, Adams DJ, Ng BL, Petty R, Venkitaraman AR, Arends MJ, Bradley A (2005) The RASSF1A isoform of RASSF1 promotes microtubule stability and suppresses tumorigenesis. Mol Cell Biol 25(18):8356–8367
Article
PubMed
PubMed Central
CAS
Google Scholar
De Jong WK, Verpooten GF, Kramer H, Louwagie J, Groen HJ (2009) Promoter methylation primarily occurs in tumor cells of patients with non-small cell lung cancer. Anticancer Res 29(1):363–369
PubMed
Google Scholar
Shibata Y, Haruki N, Kuwabara Y, Ishiguro H, Shinoda N, Sato A, Kimura M, Koyama H, Toyama T, Nishiwaki T, Kudo J, Terashita Y, Konishi S, Sugiura H, Fujii Y (2002) Chfr expression is downregulated by CpG island hypermethylation in esophageal cancer. Carcinogenesis 23(10):1695–1699
Article
CAS
PubMed
Google Scholar
Kato K, Hara A, Kuno T, Mori H, Yamashita T, Toida M, Shibata T (2006) Aberrant promoter hypermethylation of p16 and MGMT genes in oral squamous cell carcinomas and the surrounding normal mucosa. J Cancer Res Clin Oncol 132(11):735–743
Article
CAS
PubMed
Google Scholar
Cui J, Li G, Yin J, Li L, Tan Y, Wei H, Liu B, Deng L, Tang J, Chen Y, Yi L (2020) GSTP1 and cancer: expression, methylation, polymorphisms and signaling (Review). Int J Oncol 56(4):867–878
CAS
PubMed
Google Scholar
Malhotra P, Anwar M, Kochhar R, Ahmad S, Vaiphei K, Mahmood S (2014) Promoter methylation and immunohistochemical expression of hMLH1 and hMSH2 in sporadic colorectal cancer: a study from India. Tumour Biol 35(4):3679–3687
Article
CAS
PubMed
Google Scholar
Li QF, Li QY, Gao AR, Shi QF (2015) Correlation between promoter methylation in the GSTP1 gene and hepatocellular carcinoma development: a meta-analysis. Genet Mol Res 14(2):6762–6772
Article
CAS
PubMed
Google Scholar
Heimbach JK (2017) Overview of the updated AASLD guidelines for the management of HCC. Gastroenterol Hepatol (N Y) 13(12):751–753
Google Scholar
Hoffmann J (1983) Stapler transection of the oesophagus for bleeding oesophageal varices. Scand J Gastroenterol 18(6):707–711
Article
CAS
PubMed
Google Scholar
Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R (1973) Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 60(8):646–649
Article
CAS
PubMed
Google Scholar
Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB (1996) Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 93(18):9821–9826
Article
CAS
PubMed
PubMed Central
Google Scholar
Hoque MO, Begum S, Topaloglu O, Jeronimo C, Mambo E, Westra WH, Califano JA, Sidransky D (2004) Quantitative detection of promoter hypermethylation of multiple genes in the tumor, urine, and serum DNA of patients with renal cancer. Cancer Res 64(15):5511–5517
Article
CAS
PubMed
Google Scholar
Ehrich M, Zoll S, Sur S, van den Boom D (2007) A new method for accurate assessment of DNA quality after bisulfite treatment. Nucleic Acids Res 35(5):e29
Article
PubMed
PubMed Central
Google Scholar
Holmes EE, Jung M, Meller S, Leisse A, Sailer V, Zech J, Mengdehl M, Garbe LA, Uhl B, Kristiansen G, Dietrich D (2014) Performance evaluation of kits for bisulfite-conversion of DNA from tissues, cell lines, FFPE tissues, aspirates, lavages, effusions, plasma, serum, and urine. PLoS ONE 9(4):e93933
Article
PubMed
PubMed Central
CAS
Google Scholar
Zhang C, Li J, Huang T, Duan S, Dai D, Jiang D, Sui X, Li D, Chen Y, Ding F, Huang C, Chen G, Wang K (2016) Meta-analysis of DNA methylation biomarkers in hepatocellular carcinoma. Oncotarget 7(49):81255–81267
Article
PubMed
PubMed Central
Google Scholar
Li Z, Zhang H, Yang J, Hao T, Li S (2012) Promoter hypermethylation of DNA damage response genes in hepatocellular carcinoma. Cell Biol Int 36(5):427–432
Article
CAS
PubMed
Google Scholar
Lin JC, Wu YC, Wu CC, Shih PY, Wang WY, Chien YC (2015) DNA methylation markers and serum alpha-fetoprotein level are prognostic factors in hepatocellular carcinoma. Ann Hepatol 14(4):494–504
Article
CAS
PubMed
Google Scholar
Araujo OC, Rosa AS, Fernandes A, Niel C, Villela-Nogueira CA, Pannain V, Araujo NM (2016) RASSF1A and DOK1 promoter methylation levels in hepatocellular Carcinoma, Cirrhotic and Non-Cirrhotic Liver, and Correlation with Liver Cancer in Brazilian Patients. PLoS ONE 11(4):e0153796
Article
PubMed
PubMed Central
CAS
Google Scholar
Zhang YJ, Wu HC, Shen J, Ahsan H, Tsai WY, Yang HI, Wang LY, Chen SY, Chen CJ, Santella RM (2007) Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA. Clin Cancer Res 13(8):2378–2384
Article
CAS
PubMed
Google Scholar
Liu ZJ, Huang Y, Wei L, He JY, Liu QY, Yu XQ, Li ZL, Zhang J, Li B, Sun CJ, Liang WB, Sun AM, Qin Y (2017) Combination of LINE-1 hypomethylation and RASSF1A promoter hypermethylation in serum DNA is a non-invasion prognostic biomarker for early recurrence of hepatocellular carcinoma after curative resection. Neoplasma 64(5):795–802
Article
CAS
PubMed
Google Scholar
Dong X, He H, Zhang W, Yu D, Wang X, Chen Y (2015) Combination of serum RASSF1A methylation and AFP is a promising non-invasive biomarker for HCC patient with chronic HBV infection. Diagn Pathol 10:133
Article
PubMed
PubMed Central
CAS
Google Scholar
Sakai M, Hibi K, Kanazumi N, Nomoto S, Inoue S, Takeda S, Nakao A (2005) Aberrant methylation of the CHFR gene in advanced hepatocellular carcinoma. Hepatogastroenterology 52(66):1854–1857
CAS
PubMed
Google Scholar
Chen H, Zhang T, Sheng Y, Zhang C, Peng Y, Wang X, Zhang C (2015) Methylation profiling of multiple tumor suppressor genes in hepatocellular carcinoma and the epigenetic mechanism of 3OST2 regulation. J Cancer 6(8):740–749
Article
CAS
PubMed
PubMed Central
Google Scholar
Lou C, Yang B, Gao YT, Wang YJ, Nie FH, Yuan Q, Zhang CL, Du Z (2008) Aberrant methylation of multiple genes and its clinical implication in hepatocellular carcinoma. Zhonghua Zhong Liu Za Zhi 30(11):831–836
CAS
PubMed
Google Scholar
Li CC, Yu Z, Cui LH, Piao JM, Liu M (2014) Role of P14 and MGMT gene methylation in hepatocellular carcinomas: a meta-analysis. Asian Pac J Cancer Prev 15(16):6591–6596
Article
PubMed
Google Scholar
Wang J, Qin Y, Li B, Sun Z, Yang B (2006) Detection of aberrant promoter methylation of GSTP1 in the tumor and serum of Chinese human primary hepatocellular carcinoma patients. Clin Biochem 39(4):344–348
Article
CAS
PubMed
Google Scholar
Matsukura S, Soejima H, Nakagawachi T, Yakushiji H, Ogawa A, Fukuhara M, Miyazaki K, Nakabeppu Y, Sekiguchi M, Mukai T (2003) CpG methylation of MGMT and hMLH1 promoter in hepatocellular carcinoma associated with hepatitis viral infection. Br J Cancer 88(4):521–529
Article
CAS
PubMed
PubMed Central
Google Scholar
Xu G, Zhou X, Xing J, Xiao Y, Jin B, Sun L, Yang H, Du S, Xu H, Mao Y (2020) Identification of RASSF1A promoter hypermethylation as a biomarker for hepatocellular carcinoma. Cancer Cell Int 20(1):547
Article
CAS
PubMed
PubMed Central
Google Scholar
Chan KC, Lai PB, Mok TS, Chan HL, Ding C, Yeung SW, Lo YM (2008) Quantitative analysis of circulating methylated DNA as a biomarker for hepatocellular carcinoma. Clin Chem 54(9):1528–1536
Article
CAS
PubMed
Google Scholar
Nishida N, Kudo M, Nagasaka T, Ikai I, Goel A (2012) Characteristic patterns of altered DNA methylation predict emergence of human hepatocellular carcinoma. Hepatology 56(3):994–1003
Article
CAS
PubMed
Google Scholar
Li Y, Cai Y, Chen H, Mao L (2018) Clinical significance and association of GSTP1 hypermethylation with hepatocellular carcinoma: a meta-analysis. J Cancer Res Ther 14(Supplement):S486–S489
CAS
PubMed
Google Scholar
Dekervel J, van Pelt J, Verslype C (2015) DNA methylation in hepatocellular carcinoma: What is the use? Hepat Oncol 2(4):321–323
Article
PubMed
PubMed Central
Google Scholar
Liu A, Wu Q, Peng D, Ares I, Anadon A, Lopez-Torres B, Martinez-Larranaga MR, Wang X, Martinez MA (2020) A novel strategy for the diagnosis, prognosis, treatment, and chemoresistance of hepatocellular carcinoma: DNA methylation. Med Res Rev 40(5):1973–2018
Article
CAS
PubMed
Google Scholar
Hegi ME, Diserens AC, Godard S, Dietrich PY, Regli L, Ostermann S, Otten P, Van Melle G, de Tribolet N, Stupp R (2004) Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide. Clin Cancer Res 10(6):1871–1874
Article
CAS
PubMed
Google Scholar